Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia.
Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia.
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DOI：
10.1016/j.jmmm.2015.03.085
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发表时间：
2015-08-01
影响因子：
2.7
通讯作者：
Brazel CS
中科院分区：
文献类型：
--
作者：
Shah RR;Davis TP;Glover AL;Nikles DE;Brazel CS
使用AC磁场加热纳米颗粒（NP）取决于几个因素，并且这些参数的优化可以在施用低NP治疗剂量的同时提高用于有效癌症治疗的热生成效率。研究了磁场强度和频率、纳米粒子尺寸、纳米粒子浓度和溶液粘度等影响磁性氧化铁（Fe 3 O 4）和磁赤铁矿（γ-Fe 2 O3）纳米粒子加热效率的重要参数。加热效率进行了测定，为每个实验设置，与特定的吸收率（SAR）范围从3.7至325.9 W/g铁。对在我们的实验室中合成的铁氧化物NP（平均核尺寸为8、11、13和18 nm）以及市售铁氧化物（平均核尺寸为8、9和16 nm）进行磁加热。实验性磁线圈系统使得能够隔离磁场参数的影响并独立地研究对发热的影响。最高的SAR值被发现为18 nm的合成颗粒和磁赤铁矿纳米粉末。施加的磁场强度范围为15.1至47.7 kA/m，场频率范围为123至430 kHz。最好的加热观察到的最高场强和频率测试，与Rosensweig方程预测的趋势的结果。溶液粘度的增加导致纳米颗粒溶液的加热速率降低，这对磁流体热疗在体内的应用具有重要意义。
Heating of nanoparticles (NPs) using an AC magnetic field depends on several factors, and optimization of these parameters can improve the efficiency of heat generation for effective cancer therapy while administering a low NP treatment dose. This study investigated magnetic field strength and frequency, NP size, NP concentration, and solution viscosity as important parameters that impact the heating efficiency of iron oxide NPs with magnetite (Fe3O4) and maghemite (γ-Fe2O3) crystal structures. Heating efficiencies were determined for each experimental setting, with specific absorption rates (SARs) ranging from 3.7 to 325.9 W/g Fe. Magnetic heating was conducted on iron oxide NPs synthesized in our laboratories (with average core sizes of 8, 11, 13, and 18 nm), as well as commercially-available iron oxides (with average core sizes of 8, 9, and 16 nm). The experimental magnetic coil system made it possible to isolate the effect of magnetic field parameters and independently study the effect on heat generation. The highest SAR values were found for the 18 nm synthesized particles and the maghemite nanopowder. Magnetic field strengths were applied in the range of 15.1 to 47.7 kA/m, with field frequencies ranging from 123 to 430 kHz. The best heating was observed for the highest field strengths and frequencies tested, with results following trends predicted by the Rosensweig equation. An increase in solution viscosity led to lower heating rates in nanoparticle solutions, which can have significant implications for the application of magnetic fluid hyperthermia in vivo.
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影响因子：
2.1
作者：
Krishnan KM
通讯作者：
Krishnan KM
钴铁氧体纳米颗粒的预测毒理学：使用来自数据的知识发现方法对不同细胞模型进行比较体内研究。
影响因子：
10
作者：
Horev-Azaria L;Baldi G;Beno D;Bonacchi D;Golla-Schindler U;Kirkpatrick JC;Kolle S;Landsiedel R;Maimon O;Marche PN;Ponti J;Romano R;Rossi F;Sommer D;Uboldi C;Unger RE;Villiers C;Korenstein R
通讯作者：
Korenstein R
影响因子：
8.6
作者：
Beji, Z.;Hanini, A.;Ammar, S.
通讯作者：
Ammar, S.
高性能磁热疗剂 Fe3O4 纳米粒子表面涂层的优化
影响因子：
--
作者：
Liu, Xiao Li;Fan, Hai Ming;Ding, Jun
通讯作者：
Ding, Jun
影响因子：
15
作者：
Fortin, Jean-Paul;Wilhelm, Claire;Gazeau, Florence
通讯作者：
Gazeau, Florence