Human subarachnoid space width oscillations in the resting state.
Human subarachnoid space width oscillations in the resting state.
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DOI：
10.1038/s41598-018-21038-0
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发表时间：
2018-02-15
影响因子：
4.6
通讯作者：
Winklewski PJ
中科院分区：
文献类型：
--
作者：
Gruszecki M;Lancaster G;Stefanovska A;Neary JP;Dech RT;Guminski W;Frydrychowski AF;Kot J;Winklewski PJ
患有多发性硬化症和高血压等多种疾病的患者可能会出现异常的脑脊液（CSF）脉动。CSF脉动性导致蛛网膜下腔（SAS）宽度变化，这可以用近红外透照背散射探测（NIR-T/BSS）测量。本研究的目的是将联合收割机NIR-T/BSS和小波分析方法相结合，在0.005至2 Hz的宽频率范围内研究SAS宽度的动态变化，并首次详细研究了低频。从记录在静息状态下，我们还展示了SAS宽度之间的关系，在大脑的两个半球，并探讨如何SAS宽度动态与血压（BP）。这些研究还揭示了年龄和SAS相关性对SAS宽度动态的影响及其与BP的相似性。NIR-T/BSS和时间-频率分析的组合可以在理解和诊断各种神经退行性疾病和衰老相关疾病方面开辟新的领域，以改善诊断程序和患者预后。
Abnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the SAS width within a wide range of frequencies from 0.005 to 2 Hz, with low frequencies studied in detail for the first time. From recordings in the resting state, we also demonstrate the relationships between SAS width in both hemispheres of the brain, and investigate how the SAS width dynamics is related to the blood pressure (BP). These investigations also revealed influences of age and SAS correlation on the dynamics of SAS width and its similarity with the BP. Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.
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DOI：
10.1098/rsta.2011.0622
发表时间：
2013-08-28
期刊：
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
影响因子：
--
作者：
Iatsenko D;Bernjak A;Stankovski T;Shiogai Y;Owen-Lynch PJ;Clarkson PB;McClintock PV;Stefanovska A
通讯作者：
Stefanovska A
影响因子：
5.3
作者：
Brigadoi, Sabrina;Cooper, Robert J.
通讯作者：
Cooper, Robert J.
影响因子：
0.7
作者：
Egnor, M;Zheng, LL;Davis, R
通讯作者：
Davis, R
影响因子：
2.4
作者：
Beggs, Clive B.;Magnano, Christopher;Zivadinov, Robert
通讯作者：
Zivadinov, Robert
影响因子：
3.1
作者：
Kvandal, Per;Landsverk, Svein Aslak;Kirkeboen, Knut Arvid
通讯作者：
Kirkeboen, Knut Arvid