Evolution of cardiorespiratory interactions with age.

Evolution of cardiorespiratory interactions with age.
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DOI:
10.1098/rsta.2011.0622
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发表时间:
2013-08-28
期刊:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
影响因子:
--
通讯作者:
Stefanovska A
Stefanovska A
中科院分区:
其他
文献类型:
--
作者:
Iatsenko D;Bernjak A;Stankovski T;Shiogai Y;Owen-Lynch PJ;Clarkson PB;McClintock PV;Stefanovska A

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我们对年龄在16-90岁的189名男女受试者的心脏和呼吸时间序列进行了分析。应用同步压缩小波变换提取呼吸和心脏的频率和相位,时间分辨率优于标记事件法。通过将心脏和呼吸视为耦合振荡器,我们应用基于贝叶斯推理的方法来找到潜在的耦合参数及其时间依赖性,并由此推导出同步、耦合方向性和不同机制的相对贡献等度量。我们详细分析了重建的心肺偶联功能,它的时间演变和年龄依赖性。我们发现,心率的直接和间接呼吸调节都随着年龄的增长而下降,心肺耦合变得不那么稳定,并且更具时变性。
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16–90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.
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