Constructing Cu(7)S(4)@SiO(2)/DOX Multifunctional Nanoplatforms for Synergistic Photothermal-Chemotherapy on Melanoma Tumors.
Constructing Cu(7)S(4)@SiO(2)/DOX Multifunctional Nanoplatforms for Synergistic Photothermal-Chemotherapy on Melanoma Tumors.
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构建 Cu7S4@SiO2/DOX 多功能纳米平台用于黑色素瘤协同光热化疗
DOI：
10.3389/fbioe.2020.579439
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发表时间：
2020
影响因子：
5.7
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Zhang L;Pan H;Li Y;Li F;Huang X
光热治疗与化疗相结合是一种有效的治疗策略，通过即时的热消融和长期的化学抑制，从而达到高的治疗效果。在本工作中，我们设计并制备了Cu7S4@SiO2/DOX纳米复合材料，并将其用作高效的协同光热-化学治疗黑色素瘤的纳米平台。首先合成Cu 7S 4纳米晶，然后在Cu 7S 4纳米晶表面原位生长SiO2壳层，最后在SiO2壳层中负载DOX，构建了Cu7S4@SiO2/DOX复合材料。Cu7S4@SiO2/DOX由Cu 7S 4核作为光热转换器、SiO2壳作为DOX载体和DOX作为抗癌药物模型组成。一旦暴露于1064 nm激光，Cu7S4@SiO2/DOX可以同时产生用于光热治疗的热量并加速DOX释放。当Cu7S4@SiO2/DOX注射到肿瘤中心时，肿瘤在近红外激光照射下迅速升温，通过协同光热-化疗显著抑制肿瘤生长，而单独光热治疗或化疗的治疗效果有限。因此，具有光热化学功能的Cu7S4@SiO2/DOX可以作为治疗实体瘤的优良纳米平台，具有较高的理论效果。
The integration of photothermal therapy and chemotherapy has been recognized to be an efficient strategy through the instant thermally ablation and long-term chemical inhibition, thus achieving high therapeutical effect. In the present work, we designed and prepared Cu7S4@SiO2/DOX nanocomposites and used them as efficient nanoplatforms for synergistic photothermal-chemo therapy on melanoma tumors. The Cu7S4@SiO2/DOX was constructed by firstly synthesizing Cu7S4 nanocrystals, then in situ growing SiO2 shell on the surface of Cu7S4 nanocrystals, and finally loading DOX within SiO2 shell. The Cu7S4@SiO2/DOX was composed of Cu7S4 core as the photothermal transducer, SiO2 shell as DOX carrier and DOX as the model of anticancer drug. Once exposed to a 1064 nm laser, the Cu7S4@SiO2/DOX could simultaneous generate heat for photothermal therapy and accelerate the DOX release. When the Cu7S4@SiO2/DOX was injected into the center of tumor, the tumor exhibit rapid temperature elevation once exposed to the NIR laser and the tumor growth is significantly inhibited through the synergistic photothermal-chemo therapy, in comparison to the limited therapeutical effect of photothermal therapy or chemotherapy alone. Therefore, the Cu7S4@SiO2/DOX with photothermal-chemo function can be used as excellent nanoplatforms for treating solid tumor with high theoretical effect.
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影响因子：
41.2
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