Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus.
Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus.
复制标题
DOI：
10.1016/j.neuron.2021.08.013
复制
发表时间：
2021-11-17
期刊：
影响因子：
16.2
通讯作者：
Dragoi G
中科院分区：
文献类型：
--
作者：
Liu K;Sibille J;Dragoi G
我们一整天都在学习和记忆各种新的经历。能够持续快速学习并在没有重大干扰的情况下形成众多连续经验的不同表征的神经原理尚不清楚。为了理解这一过程，在这里，我们询问了海马位置细胞的集合，因为大鼠在连续16小时的时间内探索了15个与睡眠时段交织的新线性环境。值得注意的是，我们发现，一个人口的位置细胞的选择性环境的方向和拓扑结构。这种方向选择性属性使网络级的区分和多个环境之间的重新映射产生偏差。新的环境表征迅速成为更通用的，但在环境中的重复经验随后增强了它们的可辨别性。对不同环境的先验经验进行概括，从而通过增强生成预测代码提高了未来新环境表示的网络可预测性。这些编码方案揭示了一个高容量，高效率的神经元框架，用于快速表示具有最佳区分-泛化平衡和减少干扰的众多连续经验。Liu等人报告说，海马位置细胞群体显示出对空间背景方向和拓扑结构的选择性，这使多个背景之间的区分和重新映射产生偏差。在一个上下文中重复的经验增强了其表征的可区分性，而跨多个上下文的泛化则提高了未来新的上下文表征的网络可预测性。
We learn and remember multiple new experiences throughout the day. The neural principles enabling continuous rapid learning and formation of distinct representations of numerous sequential experiences without major interference are not understood. To understand this process, here we interrogated ensembles of hippocampal place cells as rats explored 15 novel linear environments interleaved with sleep sessions over continuous 16-hour periods. Remarkably, we found that a population of place cells were selective to environment orientation and topology. This orientation selectivity property biased the network-level discrimination and re/mapping between multiple environments. Novel environmental representations emerged rapidly as more generic, but repeated experience within the environments subsequently enhanced their discriminability. Generalization of prior experience with different environments consequently improved network predictability of future novel environmental representations via strengthened generative predictive codes. These coding schemes reveal a high-capacity, high-efficiency neuronal framework for rapid representation of numerous sequential experiences with optimal discrimination-generalization balance and reduced interference. Liu et al. report that a population of hippocampal place cells display selectivity to spatial context orientation and topology, which biases the discrimination and remapping between multiple contexts. Repeated experience within a context enhances its representation discriminability while generalization across multiple contexts improves network predictability of future novel context representations.
登录
查看更多内容
我们能否调和关于海马功能的陈述性记忆和空间导航观点？
影响因子：
16.2
作者：
Eichenbaum H;Cohen NJ
通讯作者：
Cohen NJ
DOI：
10.1073/pnas.1214107109
发表时间：
2012-11-20
影响因子：
11.1
作者：
Mankin, Emily A.;Sparks, Fraser T.;Leutgeb, Jill K.
通讯作者：
Leutgeb, Jill K.
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
25
作者：
Brandon, Mark P.;Bogaard, Andrew R.;Hasselmo, Michael E.
通讯作者：
Hasselmo, Michael E.
影响因子：
4
作者：
Cumin, D.;Unsworth, C. P.
通讯作者：
Unsworth, C. P.