Acetamiprid Accumulates in Different Amounts in Murine Brain Regions.
Acetamiprid Accumulates in Different Amounts in Murine Brain Regions.
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DOI：
10.3390/ijerph13100937
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发表时间：
2016-09-22
影响因子：
--
通讯作者：
Sakabe K
中科院分区：
文献类型：
--
作者：
Terayama H;Endo H;Tsukamoto H;Matsumoto K;Umezu M;Kanazawa T;Ito M;Sato T;Naito M;Kawakami S;Fujino Y;Tatemichi M;Sakabe K
新烟碱类化合物如啶虫脒（ACE）属于一类新的和广泛使用的农药。新烟碱模拟尼古丁的化学结构，并与尼古丁乙酰胆碱受体（nAchR）共享激动剂活性。新烟碱类被广泛认为对人类是安全的;然而，它们最近与许多人类健康疾病有关。还报告了与动物给予高剂量类尼古丁相关的各种肌肉骨骼和神经肌肉疾病。因此，我们使用小鼠模型来研究中枢神经系统对ACE治疗的反应。我们的研究结果表明，暴露于含ACE的水三天或七天（无明显不良作用水平（NOAEL）/天的十倍和百倍）导致10周龄A/JJmsSlc（A/J）小鼠体重下降。然而，治疗并不影响脑组织学或CD 34的表达。ACE浓度显着高于正常组和溶剂组的中脑ACE治疗的小鼠。正常小鼠嗅球和中脑中α7、α4和β2 nAChRs的表达水平较低。此外，在实验组（含100倍ACE的水7天）中，许多脑区的β2 nAChR表达降低。关于脑各区域中累积的ACE量和乙酰胆碱受体表达水平的信息对于理解可能与ACE暴露相关的任何临床症状都很重要。
Neonicotinoids such as acetamiprid (ACE) belong to a new and widely used single class of pesticides. Neonicotinoids mimic the chemical structure of nicotine and share agonist activity with the nicotine acetylcholine receptor (nAchR). Neonicotinoids are widely considered to be safe in humans; however, they have recently been implicated in a number of human health disorders. A wide range of musculoskeletal and neuromuscular disorders associated with high doses of neonicotinoids administered to animals have also been reported. Consequently, we used a mouse model to investigate the response of the central nervous system to ACE treatment. Our results show that exposure to ACE-containing water for three or seven days (decuple and centuple of no observable adverse effect level (NOAEL)/day) caused a decrease in body weight in 10-week old A/JJmsSlc (A/J) mice. However, the treatments did not affect brain histology or expression of CD34. ACE concentrations were significantly higher in the midbrain of ACE-treated mice than that of the normal and vehicle groups. Expression levels of α7, α4, and β2 nAChRs were found to be low in the olfactory bulb and midbrain of normal mice. Furthermore, in the experimental group (centuple ACE-containing water for seven days), β2 nAChR expression decreased in many brain regions. Information regarding the amount of accumulated ACE and expression levels of the acetylcholine receptor in each region of the brain is important for understanding any clinical symptoms that may be associated with ACE exposure.
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DOI：
10.1007/s11356-014-3332-7
发表时间：
2015-01
期刊：
Environmental science and pollution research international
影响因子：
--
作者：
Bonmatin JM;Giorio C;Girolami V;Goulson D;Kreutzweiser DP;Krupke C;Liess M;Long E;Marzaro M;Mitchell EA;Noome DA;Simon-Delso N;Tapparo A
通讯作者：
Tapparo A
DOI：
10.1080/15287390701613140
发表时间：
2008-01-01
影响因子：
2.6
作者：
Abou-Donia, Mohamed B.;Goldstein, Larry B.;Abdel-Rahman, Ali A.
通讯作者：
Abdel-Rahman, Ali A.
影响因子：
4.3
作者：
Bhardwaj, Shipra;Srivastava, M. K.;Srivastava, L. P.
通讯作者：
Srivastava, L. P.
影响因子：
2.8
作者：
Forrester, M. B.
通讯作者：
Forrester, M. B.
影响因子：
4.2
作者：
Li, Ping;Ann, Jason;Akk, Gustav
通讯作者：
Akk, Gustav