Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population.
Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population.
复制标题
DOI：
10.1016/j.annepidem.2011.07.004
复制
发表时间：
2011-11
影响因子：
5.6
通讯作者：
Weinstein, Maxine
中科院分区：
文献类型：
--
作者：
Dowd, Jennifer Beam;Goldman, Noreen;Weinstein, Maxine
睡眠时间长短和睡眠质量与健康有关，包括全因死亡率、心血管疾病、糖尿病和肥胖。炎症可能在这些关联中起中介作用。我们研究了2000年和2006年社会环境和衰老生物标志物研究（SEBAS）的1020名受访者中炎症和自我报告的睡眠特征之间的关系，SEBAS是一项具有全国代表性的台湾53岁及以上成年人的调查。回归模型用于估计炎症（IL-6、CRP、纤维蛋白原、e-选择素、sICAM-1、白蛋白和WBC）与改进的匹兹堡睡眠质量指数（PSQI）、指数子成分和自我报告的睡眠时间之间的横断面关系。2000年至2006年间炎症标志物的变化也被用来预测2006年睡眠时间的长短。炎症与睡眠质量的总体指标无关。然而，睡眠时间越长（大约8小时），炎症水平越高。在调整腰围、自我报告的健康状况下降、糖尿病、关节炎/风湿病、心脏病和抑郁症状后，这些关联仍然存在。从多项指标来看，2000年至2006年间炎症的增加与2006年睡眠时间长而非短有关。睡眠时间过长可能是老年人群潜在炎症性疾病的标志。未来的研究应该探索炎症是否解释了观察到的长时间睡眠和死亡率之间的关系。
Short and long sleep duration and sleep quality are associated with health including all-cause mortality, cardiovascular disease, diabetes, and obesity. Inflammation may play a role in mediating these associations. We examined associations between inflammation and self-reported sleep characteristics in 1020 respondents of the 2000 and 2006 Social Environment and Biomarkers of Aging Study (SEBAS), a nationally representative survey of Taiwanese adults ages 53 and over. Regression models were used to estimate cross-sectional relationships between inflammation (IL-6, CRP, fibrinogen, e-selectin, sICAM-1, albumin, and WBC) and a modified Pittsburgh Sleep Quality Index (PSQI), index subcomponents, and self-reported sleep duration. Change in inflammatory markers between 2000 and 2006 was also used to predict long or short sleep duration in 2006. Inflammation was not related to the overall index of sleep quality. However, longer sleep (> 8 hours) was associated with higher levels of inflammation. These associations remained after adjustment for waist circumference, self-reported health decline, diabetes, arthritis/rheumatism, heart disease, and depressive symptoms. Increases in inflammation between 2000 and 2006 were associated with long but not short sleep duration in 2006 for several markers. Long sleep duration may be a marker of underlying inflammatory illness in older populations. Future studies should explore whether inflammation explains observed relationships between long sleep and mortality.
登录
查看更多内容
影响因子：
3.3
作者：
McDade, Thomas W.;Hawkley, Louise C.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.
影响因子：
10.5
作者：
Grandner, Michael A.;Hale, Lauren;Moore, Melisa;Patel, Nirav P.
通讯作者：
Patel, Nirav P.
中国中老年人睡眠质量：分布、相关因素及其与心脏代谢危险因素的关联。
影响因子：
4.5
作者：
Haseli-Mashhadi N;Dadd T;Pan A;Yu Z;Lin X;Franco OH
通讯作者：
Franco OH
影响因子：
3.3
作者：
Liukkonen, Timo;Raesaenen, Pirkko;Timonen, Markku
通讯作者：
Timonen, Markku
影响因子：
2.8
作者：
Kohout, F J;Berkman, L F;Cornoni-Huntley, J
通讯作者：
Cornoni-Huntley, J