Are serum estrogen concentrations associated with menopausal symptom bother among postmenopausal women? Baseline results from two MsFLASH clinical trials.
Are serum estrogen concentrations associated with menopausal symptom bother among postmenopausal women? Baseline results from two MsFLASH clinical trials.
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DOI：
10.1016/j.maturitas.2022.04.003
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发表时间：
2022-08
期刊：
影响因子：
4.9
通讯作者：
Diem, Susan
中科院分区：
文献类型：
--
作者：
Crandall, Carolyn J.;Larson, Joseph C.;Ensrud, Kristine E.;LaCroix, Andrea Z.;Guthrie, Katherine A.;Reed, Susan D.;Bhasin, Shalender;Diem, Susan
关键词：
目的：评价单项测定血清雌二醇(E_2)、雌酮(E_1)和性激素结合球蛋白(SHBG)浓度是否能区分有无绝经症状的妇女。我们分析了2012-2017年间进行的两项临床试验的基线数据：MsFLASH 03(178名围绝经期/绝经后女性，年龄40-62岁，有烦人的血管运动症状，平均年龄54岁)和MsFLASH 05(181名绝经后女性，年龄45-70岁，有中到重度外阴阴道症状，平均年龄61岁)。采用更年期生活质量问卷对患者过去一个月的症状(潮热或潮红、盗汗、出汗、肌肉关节疼痛、性欲改变、性交时阴道干燥、避免亲密)进行评估。使用Logistic回归，我们计算了受试者操作特征曲线(AuC值)下的面积(AUC值)，与每个试验研究人群中的每个症状至少有些困扰(症状困扰评分≥3)有关。MsFLASH 03的AUC值(95%可信区间)在0.51(0.41-0.60)至0.62(0.53，0.72)之间，MsFLASH 05的AUC值在0.51(0.42，0.59)至0.64(0.53，0.75)之间。几乎没有证据表明血清激素水平与特定更年期症状带来的困扰之间存在关联。这些发现不支持单独测量血清中的E1、E2或SHBG浓度来区分哪些妇女有特定的更年期症状，哪些妇女没有。
To evaluate whether a single measure of serum estradiol (E2), estrone (E1) and sex hormone-binding globulin (SHBG) concentration distinguishes between women with and without menopausal symptom bother. We analyzed baseline data from two clinical trials conducted in 2012-2017: MsFLASH 03 (178 peri-/post-menopausal women aged 40-62 years with bothersome vasomotor symptoms, mean age 54) and MsFLASH 05 (181 post-menopausal women aged 45-70 years with moderate-to-severe vulvovaginal symptoms, mean age 61). Symptom bother (hot flushes or flashes, night sweats, sweating, aching in muscles and joints, change in sexual desire, vaginal dryness during intercourse, and avoiding intimacy) in the past month was assessed using the Menopause-Specific Quality of Life questionnaire. Using logistic regression, we calculated the area under the receiver operating characteristic curve (AUC) values for E1, E2, and SHBG concentration in relation to being at least somewhat bothered (symptom bother score ≥3) by each symptom within each trial study population. AUC values (95% confidence interval) ranged between 0.51 (0.41-0.60) and 0.62 (0.53, 0.72) for MsFLASH 03 and between 0.51 (0.42, 0.59) and 0.64 (0.53, 0.75) for MsFLASH 05. There was little evidence of associations between serum hormone levels and bother by a given menopausal symptom. These findings do not support the clinical utility of a single measure of serum of E1, E2, or SHBG concentrations in differentiating between women who are bothered by a given menopausal symptom and those who are not.
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影响因子：
12.7
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通讯作者：
Matthews, Karen
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