Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia.
Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia.
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DOI：
10.1111/jvim.16023
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发表时间：
2021-01
影响因子：
2.6
通讯作者：
Olby NJ
中科院分区：
文献类型：
--
作者：
Sparks CR;Woelfel C;Robertson I;Olby NJ
据报道，在骑士查尔斯王犬（CKCS）中出现了腰椎脊髓膨出（SM）、腰骶部疼痛和更多的尾侧脊髓终止。缺乏关于其脊髓终末结构改变的临床相关性的数据。比较脊髓终末水平和终丝内长度（FTIL）与CKCS中腰椎SM和临床体征的存在。48个CKCS在这项前瞻性研究中，使用主人和临床医生评估对疼痛进行量化。通过矢状面磁共振成像（MRI）序列确定脊髓和硬膜囊终止的椎体水平、SM的存在和FTIL。Kappa和组内相关性（ICC）分析确定了观察者间的可靠性。将MRI结果与主人和临床医生报告的疼痛量化进行比较。脊髓和硬膜囊终止的观察者间可靠性良好（kappa分别为0.61和0.64），FTIL的观察者间可靠性极好（ICC：92%一致性）。脊髓终止于第6腰椎1例，第7腰椎31例，骶骨15例，终止水平与腰椎SM相关（P = 0.002），但与临床体征无关。平均FTIL为2.9 ± 1.08 mm;与主人报告的疼痛（P = 0.033）和脊柱触诊评分（P = 0.023）相关。与正常CKCS和伴SM的疼痛CKCS相比，不伴SM的疼痛CKCS的FTIL较短（P = .02）。没有SM的疼痛性CKCS缩短了脊髓末端和硬膜囊之间的距离，表明FTIL较短。更多的尾侧脊髓终止与腰椎SM的发生相关。
Lumbar syringomyelia (SM), lumbosacral pain, and more caudal spinal cord termination are reported in Cavalier King Charles spaniels (CKCS). Data are lacking on the clinical relevance of alterations in their spinal cord terminal structures. To compare spinal cord termination level and filum terminale internum length (FTIL) with presence of lumbar SM and clinical signs in CKCS. Forty‐eight CKCS. In this prospective study, pain was quantified using owner and clinician assessments. Vertebral level of spinal cord and dural sac termination, presence of SM, and FTIL were determined from sagittal magnetic resonance imaging (MRI) sequences. Kappa and intraclass correlation (ICC) analyses determined interobserver reliability. The MRI findings were compared to owner and clinician‐reported pain quantification. Interobserver reliability was good for spinal cord and dural sac termination (kappa = 0.61 and 0.64, respectively) and excellent for FTIL (ICC: 92% agreement). The spinal cord terminated at 6th lumbar vertebra in 1, 7th lumbar vertebra in 31, and the sacrum in 15 dogs, and termination level was associated with lumbar SM (P = .002) but not clinical signs. Mean FTIL was 2.9 ± 1.08 mm; it was associated with owner‐reported pain (P = .033) and spinal palpation scores (P = .023). Painful CKCS without SM had shorter FTIL compared to normal CKCS and painful CKCS with SM (P = .02). Painful CKCS without SM have decreased distance between the termination of the spinal cord and dural sac, suggesting a shorter FTIL. More caudal spinal cord termination is associated with development of lumbar SM.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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