Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses.
Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses.
复制标题
在持续类似焦虑的恐惧样反应中，质子末端和CRF的床核的选择性参与。
DOI：
10.1016/j.pnpbp.2009.06.022
复制
发表时间：
2009-11-13
影响因子：
5.6
通讯作者：
Davis, M.
中科院分区：
文献类型：
--
作者：
Walker, D. L.;Miles, L. A.;Davis, M.
杏仁中央核的内侧分支（CeAM）和终纹床核的外侧分支（BNSTL）关系密切。两者都接受来自基底外侧杏仁核（BLA）的投射，并且都投射到调节受恐惧影响的行为的大脑区域。然而，与CeAM相反，最初试图将BNST与条件性恐惧反应联系起来的尝试基本上没有成功。最近的研究表明，BNST确实参与了某些类型的焦虑和压力反应。在这里，我们回顾了证据表明CeAM和BNSTL在功能上是互补的，CeAM介导了短而不是长时间的威胁反应（即，阶段性恐惧）和BNSTL介导长而非短持续时间反应（持续恐惧或“焦虑”）。我们还回顾了与应激相关的促肾上腺皮质激素释放因子（CRF）在持续但非阶段性威胁反应中的研究结果，并试图将这些研究结果整合到一个神经回路模型中，该模型解释了这些和相关的观察结果。
The medial division of the central nucleus of the amygdala (CeAM) and the lateral division of the bed nucleus of the stria terminalis (BNSTL) are closely related. Both receive projections from the basolateral amygdala (BLA) and both project to brain areas that mediate fear-influenced behaviors. In contrast to CeAM however, initial attempts to implicate the BNST in conditioned fear responses were largely unsuccessful. More recent studies have shown that the BNST does participate in some types of anxiety and stress responses. Here, we review evidence suggesting that the CeAM and BNSTL are functionally complementary, with CeAM mediating short- but not long-duration threat responses (i.e., phasic fear) and BNSTL mediating long- but not short-duration responses (sustained fear or ‘anxiety’). We also review findings implicating the stress-related peptide corticotropin-releasing factor (CRF) in sustained but not phasic threat responses, and attempt to integrate these findings into a neural circuit model which accounts for these and related observations.
登录
查看更多内容
影响因子：
5.3
作者：
CAMPEAU, S;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
5.8
作者：
Behan, DP;Khongsaly, O;deSouza, EB
通讯作者：
deSouza, EB
影响因子：
2.7
作者：
BLANCHARD, RJ;YUDKO, EB;BLANCHARD, DC
通讯作者：
BLANCHARD, DC
影响因子：
2.5
作者：
ALLEN, LS;GORSKI, RA
通讯作者：
GORSKI, RA
影响因子：
7.6
作者：
Cecchi, Marco;Capriles, Nancy;Akil, Huda
通讯作者：
Akil, Huda