The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage.
The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage.
复制标题
鼻内催产素对按摩形式社交接触的神经和行为反应的影响
DOI：
10.3389/fnins.2020.589878
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发表时间：
2020
影响因子：
4.3
通讯作者：
Yao S
中科院分区：
文献类型：
--
作者：
Chen Y;Li Q;Zhang Q;Kou J;Zhang Y;Cui H;Wernicke J;Montag C;Becker B;Kendrick KM;Yao S
手动按摩可以有效地增加内源性催产素浓度和社会认知和奖励区域的神经活动，鼻内催产素可以增加社会接触的愉悦感。在本研究中，我们调查是否鼻内催产素调制行为和神经反应，手动或机器使用随机安慰剂对照受试者内的药物功能磁共振成像设计的足部按摩。46名男性参与者接受了每种类型的按摩块，他们都接受和想象接受按摩。鼻内催产素显著增加了手动按摩的主观愉快度，但对机器按摩和涉及奖励的关键区域的神经反应没有影响（眶额皮质、背侧纹状体和腹侧被盖区）、社会认知（上级颞叶沟和顶下小叶）、情绪和突显性（杏仁核、前扣带回和岛叶）和默认模式网络这些区域包括内侧前额叶皮层、海马旁回、后扣带回和楔前叶）以及许多感觉和运动处理区域。催产素对神经和行为的影响与受试者认为按摩师是男性还是女性无关。这些研究结果支持催产素的重要性，以增强积极的行为和神经反应的社会触摸的形式手动管理的按摩，鼻内催产素和按摩的组合可能有治疗自闭症的潜力。催产素对社交接触的影响;注册ID：NCT 03278860; URL：https://clinicaltrials.gov/ct2/show/NCT03278860。
Manually-administered massage can potently increase endogenous oxytocin concentrations and neural activity in social cognition and reward regions and intranasal oxytocin can increase the pleasantness of social touch. In the present study, we investigated whether intranasal oxytocin modulates behavioral and neural responses to foot massage applied manually or by machine using a randomized placebo-controlled within-subject pharmaco-fMRI design. 46 male participants underwent blocks of massage of each type where they both received and imagined receiving the massage. Intranasal oxytocin significantly increased subjective pleasantness ratings of the manual but not the machine massage and neural responses in key regions involved in reward (orbitofrontal cortex, dorsal striatum and ventral tegmental area), social cognition (superior temporal sulcus and inferior parietal lobule), emotion and salience (amygdala and anterior cingulate and insula) and default mode networks (medial prefrontal cortex, parahippocampal gyrus, posterior cingulate, and precuneus) as well as a number of sensory and motor processing regions. Both neural and behavioral effects of oxytocin occurred independent of whether subjects thought the massage was applied by a male or female masseur. These findings support the importance of oxytocin for enhancing positive behavioral and neural responses to social touch in the form of manually administered massage and that a combination of intranasal oxytocin and massage may have therapeutic potential in autism. The Effects of Oxytocin on Social Touch; registration ID: NCT03278860; URL: https://clinicaltrials.gov/ct2/show/NCT03278860.
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影响因子：
2.6
作者：
Case LK;Pineda J;Ramachandran VS
通讯作者：
Ramachandran VS
影响因子：
4.8
作者：
Costa, Vincent D.;Lang, Peter J.;Sabatinelli, Dean;Versace, Francesco;Bradley, Margaret M.
通讯作者：
Bradley, Margaret M.
催产素可增加情感触觉和眶额皮层活动的愉悦感，与价态无关
影响因子：
5.6
作者：
Chen, Yuanshu;Becker, Benjamin;Yao, Shuxia
通讯作者：
Yao, Shuxia
影响因子：
4.1
作者：
de Oliveira, Danielle C. G.;Zuardi, Antonio W.;Crippa, Jose A. S.
通讯作者：
Crippa, Jose A. S.
影响因子：
3
作者：
Björnsdotter M;Gordon I;Pelphrey KA;Olausson H;Kaiser MD
通讯作者：
Kaiser MD