Acute ethanol reduces reversal cost in discrimination learning by reducing perseverance in adolescent rhesus macaques.
Acute ethanol reduces reversal cost in discrimination learning by reducing perseverance in adolescent rhesus macaques.
复制标题
DOI：
10.1111/acer.12050
复制
发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Taffe MA
中科院分区：
文献类型：
--
作者：
Wright MJ Jr;Glavis-Bloom C;Taffe MA
Acute alcohol exposure produces cognitive deficits in adults but less is known about the acute cognitive effects of alcohol in adolescents. The cognitive impact of acute alcohol exposure includes deficits in discrimination and reversal learning, but traditional experimental approaches make it difficult to distinguish the effect of alcohol on discrimination learning from the effect of alcohol on reversal learning. Young rhesus macaques can be used to model some aspects of human adolescence because of their anatomical, neurophysiological and cognitive similarities with humans. Adolescent male rhesus monkeys (N=10) were trained to respond to visual stimuli on touch-sensitive LCD panels controlled by the nonhuman primate version of CANTAB software. Discrimination and reversal learning tasks were subsequently assessed after monkeys were allowed to consume varying amounts of ethanol in a flavored vehicle (vehicle only, up to 0.5 g/kg ethanol, up to 1.0 g/kg ethanol and up to 1.5 g/kg ethanol). Acute exposure to ethanol reduced perseverance, increased response accuracy, and reduced errors during reversal learning when the task was completed within 90 minutes of ethanol consumption. No reduction in reversal errors was observed when ethanol was consumed 3 or 24 hrs prior to reversal learning. Ethanol only impaired discrimination learning when monkeys had very little previous ethanol exposure. The temporal relationship between ethanol consumption and reversal learning was consistent with selective ethanol-induced impairment of retrieval, but not storage, processes. This was evidenced by diminished perseverance on the previously correct stimulus leading to decreased errors to criterion.
登录
查看更多内容
影响因子：
4.1
作者：
Pearce, PC;Crofts, HS;Scott, EAM
通讯作者：
Scott, EAM
影响因子：
3.6
作者：
PIEPER W A;SKEEN M J
通讯作者：
SKEEN M J
影响因子：
2.3
作者：
Chin, Vivien S.;Van Skike, Candice E.;Matthews, Douglas B.
通讯作者：
Matthews, Douglas B.
影响因子：
2.3
作者：
Acheson, SK;Ross, EL;Swartzwelder, HS
通讯作者：
Swartzwelder, HS
DOI：
10.1111/j.1530-0277.1998.tb03668.x
发表时间：
1998-04-01
影响因子：
3.2
作者：
Markwiese, BJ;Acheson, SK;Swartzwelder, HS
通讯作者：
Swartzwelder, HS