Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study.
Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study.
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DOI：
10.1038/srep37817
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发表时间：
2016-12-02
影响因子：
4.6
通讯作者：
Chen JH
中科院分区：
文献类型：
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作者：
Chang CC;Chang YS;Chen WS;Chen YH;Chen JH
关于流感疫苗对系统性红斑狼疮（SLE）患者的临床疗效的研究很少。本研究比较了有和无流感疫苗接种的SLE患者队列的住院率、发病率和死亡率。我们使用2001年至2012年台湾的保险索赔数据，确定每年有（N = 1765）和没有（N = 8360）流感疫苗接种的SLE成人患者。测量疫苗和非疫苗队列的发病率比和发病率和死亡率的风险比（HR）。疫苗组的住院率低于非疫苗组，校正后的HR为0.82（95%CI 0.73-0.92）。此外，接种疫苗的队列不太可能进入重症监护室[校正HR 0.55（95% CI 0.39-0.79）]，因败血症、菌血症或病毒血症住院[校正HR 0.48（95% CI 0.32-0.73）]，接受院内透析[校正HR 0.40（95% CI 0.20-0.81）]，死亡倾向较低[校正HR 0.41（95% CI 0.27-0.61）]。总之，SLE患者接种流感疫苗与发病率和死亡率风险降低相关。
Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan’s insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts. The vaccine cohort had a lower hospitalization rate than did the nonvaccine cohort, with an adjusted HR of 0.82 (95% CI 0.73–0.92). Furthermore, the vaccine cohort was less likely to be admitted to the intensive care unit [adjusted HR 0.55 (95% CI 0.39–0.79)], to be hospitalized for septicemia, bacteremia, or viremia [adjusted HR 0.48 (95% CI 0.32–0.73)], to undergo in-hospital dialysis [adjusted HR 0.40 (95% CI 0.20–0.81)], and were less predisposed to death [adjusted HR 0.41 (95% CI 0.27–0.61)]. In conclusion, influenza vaccination in patients with SLE is associated with a reduced risk of morbidity and mortality.
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影响因子：
11.8
作者：
Glueck, T.;Mueller-Ladner, U.
通讯作者：
Mueller-Ladner, U.
影响因子：
27.4
作者：
Mosca M;Tani C;Aringer M;Bombardieri S;Boumpas D;Brey R;Cervera R;Doria A;Jayne D;Khamashta MA;Kuhn A;Gordon C;Petri M;Rekvig OP;Schneider M;Sherer Y;Shoenfeld Y;Smolen JS;Talarico R;Tincani A;van Vollenhoven RF;Ward MM;Werth VP;Carmona L
通讯作者：
Carmona L
影响因子：
120.7
作者：
FEDSON, DS
通讯作者：
FEDSON, DS
影响因子：
13.6
作者：
Conti, Fabrizio;Rezai, Soheila;Valesini, Guido
通讯作者：
Valesini, Guido
DOI：
10.1016/s0140-6736(03)14854-4
发表时间：
2003-11-22
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nicholson KG;Wood JM;Zambon M
通讯作者：
Zambon M