Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels
Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels
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用于电惊厥治疗结果预测的新型癫痫发作质量指数与脑源性神经营养因子血清水平之间的关联
DOI：
10.1016/j.neulet.2019.04.023
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发表时间：
2019
影响因子：
2.5
通讯作者：
Sartorius A
中科院分区：
文献类型：
--
作者：
Kranaster L;Hellweg R;Sartorius A
新的癫痫发作质量指数（SQI）可以根据抑郁症患者癫痫发作的几个关键参数的程度，预测早在第二次电休克治疗（ECT）后无反应和无缓解的风险。本研究评估了这些指标与外周血血清脑源性神经营养因子（BDNF）水平之间的关系。提示抑郁症患者ECT后SQI反映的癫痫发作质量与血清BDNF水平呈正相关。我们纳入了36名患者，他们有完整的数据集，完成了ECT疗程，并在ECT疗程前后观察了BDNF水平。基线血清BDNF水平（2838.9 pg/ml±1659.9）低于ECT后平均BDNF水平（3206.3 pg/ml±1532.3），但统计学检验没有达到显著性（z = 1.96, p = 0.051, r = 0.23）。在亚组分析中，在年龄小于65岁的患者中，ECT后的BDNF水平与SQI总评分呈正相关（rs= 0.62, p = 0.018）和缓解（rs= 0.57, p = 0.033）， SQI已建立并验证。这表明癫痫发作质量和ECT抗抑郁反应之间的一个联系可能是BDNF。
The novel Seizure Quality Index (SQI) could predict the risk of non-response and non-remission as early as after the second electroconvulsive therapy (ECT) session based the extent of several ictal parameters of the seizure in patients with depression. The association between those indices with the peripheral serum levels of brain-derived neurotrophic factor (BDNF) was evaluated in this study. It was proposed that seizure quality reflected by the SQI will be positively correlated with the levels of serum BDNF after ECT in patients with depression. We included 36 patients with a full data set, a completed course of ECT and BDNF levels before and after that ECT course. Baseline serum BDNF levels (2838.9 pg/ml ±1659.9) were lower compared to the mean BDNF levels after ECT (3206.3 pg/ml ±1532.3), but the statistical test did not reach significance (z = 1.96, p = 0.051, r = 0.23). In a sub-group analysis, the BDNF levels after ECT were positively correlated with the SQI sum score for response (rs= 0.62, p = 0.018) and for remission (rs= 0.57, p = 0.033) in patients younger than 65 years, the group, for whom the SQI has been built and validated. This suggests that one link between seizure quality and antidepressant response to ECT could be BDNF.
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影响因子：
158.5
作者：
SACKEIM, HA;PRUDIC, J;SETTEMBRINO, JM
通讯作者：
SETTEMBRINO, JM
癫痫充分性标记和电惊厥治疗反应的预测
影响因子：
2.5
作者：
A. Minelli;M. Abate;E. Zampieri;G. Gainelli;L. Trabucchi;M. Segala;R. Sartori;M. Gennarelli;A. Conca;M. Bortolomasi
通讯作者：
M. Bortolomasi
影响因子：
3.3
作者：
Bakos, J.;Hlavacova, N.;Jezova, D.
通讯作者：
Jezova, D.
电极放置对滴定低剂量 ECT 疗效的影响。
DOI：
10.1176/ajp.144.11.1449
发表时间：
1987
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Sackeim,HA;Decina,P;Kanzler,M;Kerr,B;Malitz,S
通讯作者：
Malitz,S
DOI：
10.1007/s00406-014-0543-3
发表时间：
2015-04-01
影响因子：
4.7
作者：
Bumb, Jan Malte;Aksay, Suna Su;Sartorius, Alexander
通讯作者：
Sartorius, Alexander