Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.
Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.
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DOI：
10.1289/ehp.1205901
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发表时间：
2013-09
影响因子：
10.4
通讯作者：
Longnecker MP
中科院分区：
文献类型：
--
作者：
Cupul-Uicab LA;Klebanoff MA;Brock JW;Longnecker MP
背景：在之前的一些研究中，产前接触持久性有机氯，如 1,1,-二氯-2,2-双（对氯苯基）乙烯 (p,p´-DDE)、多氯联苯 (PCB) 和六氯苯 (HCB) 与儿童较高的体重指数 (BMI) 相关。目的：我们的目标是评估母体血清中β-六氯环己烷 (β-HCH)、对,对'-DDE、二氯二苯基三氯乙烷 (p,p'-DDT)、狄氏剂、环氧化七氯、HCB、反式九氯、氯丹和 PCB 的水平与子代儿童期肥胖的关系。方法：作为美国围产期合作项目 (CPP) 的一部分，该分析基于 1,915 名儿童的子样本，随访至 7 岁。 CPP 在 1959 年至 1965 年期间招募了孕妇；在美国禁用这些有机氯之前收集的妊娠晚期母体血清中测量了暴露水平。根据国际肥胖工作组的建议，使用特定年龄和性别的 BMI 切点来定义儿童超重和肥胖。结果：调整后的结果没有显示有机氯暴露与肥胖之间存在关联的明确证据；然而，针对狄氏剂出现了一项具有启发性的发现。与最低五分之一的人（狄氏剂，< 0.57 μg/L）相比，第四个五分之一的肥胖几率为 3.6（95% CI：1.3，10.5），最高五分之一的肥胖几率为 2.3（95% CI：0.8，7.1）。超重和体重指数与有机氯暴露无关。结论：在有机氯暴露水平相对较高的人群中，与肥胖或体重指数没有明显的关联。引用: Cupul-Uicab LA、Klebanoff MA、Brock JW、Longnecker MP。 2013 年。美国围产期合作项目中的产前接触持久性有机氯和儿童肥胖。环境健康视角121：1103–1109； http://dx.doi.org/10.1289/ehp.1205901
Background: In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children. Objective: Our goal was to evaluate the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor, oxychlordane, and PCBs with offspring obesity during childhood. Methods: The analysis was based on a subsample of 1,915 children followed until 7 years of age as part of the U.S. Collaborative Perinatal Project (CPP). The CPP enrolled pregnant women in 1959–1965; exposure levels were measured in third-trimester maternal serum that was collected before these organochlorines were banned in the United States. Childhood overweight and obesity were defined using age- and sex-specific cut points for BMI as recommended by the International Obesity Task Force. Results: Adjusted results did not show clear evidence for an association between organochlorine exposure and obesity; however, a suggestive finding emerged for dieldrin. Compared with those in the lowest quintile (dieldrin, < 0.57 μg/L), odds of obesity were 3.6 (95% CI: 1.3, 10.5) for the fourth and 2.3 (95% CI: 0.8, 7.1) for the highest quintile. Overweight and BMI were unrelated to organochlorine exposure. Conclusions: In this population with relatively high levels of exposure to organochlorines, no clear associations with obesity or BMI emerged. Citation: Cupul-Uicab LA, Klebanoff MA, Brock JW, Longnecker MP. 2013. Prenatal exposure to persistent organochlorines and childhood obesity in the U.S. Collaborative Perinatal Project. Environ Health Perspect 121:1103–1109; http://dx.doi.org/10.1289/ehp.1205901
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