Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy.
Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy.
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DOI：
10.1289/ehp.1002169
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发表时间：
2011-02
影响因子：
10.4
通讯作者：
Sunyer J
中科院分区：
文献类型：
--
作者：
Mendez MA;Garcia-Esteban R;Guxens M;Vrijheid M;Kogevinas M;Goñi F;Fochs S;Sunyer J
虽然已经假设胎儿暴露于干扰内分泌的化学物质可能会增加肥胖风险，但经验数据有限，并且不确定任何影响可能在生命的早期开始。我们探讨了产前暴露于几种有机氯化合物（OC）是否与生命前6个月的快速生长和婴儿期后期的体重指数（BMI）相关。数据来自西班牙INMA（Infancia y Medio-Ambiente）儿童和环境出生队列，该队列招募了657名早孕妇女。前6个月的快速生长定义为年龄别体重z评分变化> 0.67，14个月时BMI升高定义为z评分≥第85百分位数。广义线性模型用于估计与孕早期母体血清中2，2-双（对氯苯基）-1，1-二氯乙烯（DDE）、六氯苯、β-六氯己烷和多氯联苯相关的快速生长或BMI升高的风险。在包括其他OC在内的多变量调整后，DDE暴露高于第一四分位数与体重正常（BMI < 25 kg/m2）但不超重的母亲的儿童快速生长风险加倍相关。DDE还与14个月时BMI升高相关（单位增加的相对风险log DDE = 1.50; 95%置信区间，1.11-2.03）。其他OC与调整后的快速生长或BMI升高无关。在这项研究中，我们发现产前DDE暴露与体重正常母亲的婴儿在前6个月体重快速增加和婴儿期BMI升高有关。需要更多的研究来探索化学品暴露在早发性肥胖中的潜在作用。
Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and it is uncertain how early in life any effects may begin. We explored whether prenatal exposure to several organochlorine compounds (OCs) is associated with rapid growth in the first 6 months of life and body mass index (BMI) later in infancy. Data come from the INMA (Infancia y Medio-Ambiente) Child and Environment birth cohort in Spain, which recruited 657 women in early pregnancy. Rapid growth during the first 6 months was defined as a change in weight-for-age z-scores > 0.67, and elevated BMI at 14 months, as a z-score ≥ the 85th percentile. Generalized linear models were used to estimate the risk of rapid growth or elevated BMI associated with 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), hexachlorobenzene, β-hexachlorohexane, and polychlorinated biphenyls in first-trimester maternal serum. After multivariable adjustment including other OCs, DDE exposure above the first quartile was associated with doubling of the risk of rapid growth among children of normal-weight (BMI < 25 kg/m2), but not overweight, mothers. DDE was also associated with elevated BMI at 14 months (relative risk per unit increase in log DDE = 1.50; 95% confidence interval, 1.11–2.03). Other OCs were not associated with rapid growth or elevated BMI after adjustment. In this study we found prenatal DDE exposure to be associated with rapid weight gain in the first 6 months and elevated BMI later in infancy, among infants of normal-weight mothers. More research exploring the potential role of chemical exposures in early-onset obesity is needed.
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影响因子：
4.1
作者：
Grün F;Blumberg B
通讯作者：
Blumberg B
影响因子：
2.8
作者：
Eriksson, Marit;Tynelius, Per;Rasmussen, Finn
通讯作者：
Rasmussen, Finn
影响因子：
1.8
作者：
de Onis, M.;Garza, C.;Rolland-Cachera, M. -F.
通讯作者：
Rolland-Cachera, M. -F.
影响因子：
3.8
作者：
Hitze, B.;Bosy-Westphal, A.;Mueller, M. J.
通讯作者：
Mueller, M. J.
推定的环境 - 内分泌破坏者和肥胖症：评论。
DOI：
10.1097/med.0b013e32830ce95c
发表时间：
2008-10
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Elobeid MA;Allison DB
通讯作者：
Allison DB