decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut.
decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut.
复制标题
decapentaplegic，果蝇中肠无翼信号通路的靶基因。
作者：
X. Yu;S. Hoppler;S. Eresh;M. Bienz
在果蝇表皮中，无翅信号的传递需要凌乱的、蓬松的/Zeste-white 3和犰狳。我们发现，这些基因在胚胎中肠中以相同的上位顺序传递无翅信号。除了介导同源异型基因Ultrabithorax和唇的转录刺激外，它们还需要高无翅水平的唇的转录抑制。因此，有效的唇表达仅发生在中间无翅途径活性的窗口内。最后，shaggy/zeste-white 3突变体揭示了无翅信号可以在不存在Ultrabithorax的情况下刺激decapentaplegic转录，确定decapentaplegic为无翅的靶基因。由于decapentaplegic本身是中肠中无翅表达所必需的，这代表了两个细胞群之间的正反馈回路，它们相互发出信号以刺激彼此的信号产生。
dishevelled, shaggy/zeste-white 3 and armadillo are required for transmission of the wingless signal in the Drosophila epidermis. We show that these genes act in the same epistatic order in the embryonic midgut to transmit the wingless signal. In addition to mediating transcriptional stimulation of the homeotic genes Ultrabithorax and labial, they are also required for transcriptional repression of labial by high wingless levels. Efficient labial expression thus only occurs within a window of intermediate wingless pathway activity. Finally, the shaggy/zeste-white 3 mutants revealed that wingless signalling can stimulate decapentaplegic transcription in the absence of Ultrabithorax, identifying decapentaplegic as a target gene of wingless. As decapentaplegic itself is required for wingless expression in the midgut, this represents a positive feed-back loop between two cell groups signalling to each other to stimulate each other's signal production.
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影响因子：
4.6
作者：
Heidi Theisen;Judith M. Purcell;M. Bennett;Dipul Kansagara;A. Syed;J. Marsh
通讯作者：
Heidi Theisen;Judith M. Purcell;M. Bennett;Dipul Kansagara;A. Syed;J. Marsh
影响因子：
2.7
作者：
K. Staehling‐Hampton;F. Hoffmann
通讯作者：
K. Staehling‐Hampton;F. Hoffmann
果蝇同源异型唇（实验室）基因座表达的控制：正向和负向自体调节的证据。
DOI：
10.1242/dev.113.4.1267
发表时间：
1991
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Chouinard,S;Kaufman,TC
通讯作者：
Kaufman,TC
影响因子：
4.6
作者：
M. Peifer;D. Sweeton;Michael Casey;Eric Wieschaus
通讯作者：
M. Peifer;D. Sweeton;Michael Casey;Eric Wieschaus
影响因子：
10.5
作者：
KLINGENSMITH, J;NUSSE, R;PERRIMON, N
通讯作者：
PERRIMON, N