Mechanism of suppression of sustained neuronal spiking under high-frequency stimulation.
Mechanism of suppression of sustained neuronal spiking under high-frequency stimulation.
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DOI：
10.1007/s00422-013-0567-1
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发表时间：
2013-12
影响因子：
1.9
通讯作者：
Tass, Peter Alexander
中科院分区：
文献类型：
--
作者：
Pyragas, Kestutis;Novicenko, Viktor;Tass, Peter Alexander
关键词：
以Hodgkin-Huxley和离体丘脑底核（subthalamic nucleus，HFS）模型神经元为例，研究了高频电刺激（electrical high-frequency stimulation，HFS）对神经元持续放电的抑制作用。抑制的机制解释的基础上，平均方程从原来的神经元方程在高频率的限制。我们表明，频率大大大于神经元的特征时间尺度的倒数，HFS的行动的结果是由刺激信号的振幅和频率之间的比率定义。抑制效应的出现是由于神经元的静息状态的稳定或由于其膜电位的低振幅阈下振荡的稳定。有趣的是，虽然我们忽略了突触动力学，神经环路以及神经胶质细胞的贡献，与孤立的高频刺激的神经元模型神经元获得的结果类似于临床观察到的抑制帕金森震颤所需的刺激幅度和刺激频率之间的关系。
Using Hodgkin–Huxley and isolated subthalamic nucleus (STN) model neurons as examples, we show that electrical high-frequency stimulation (HFS) suppresses sustained neuronal spiking. The mechanism of suppression is explained on the basis of averaged equations derived from the original neuron equations in the limit of high frequencies. We show that for frequencies considerably greater than the reciprocal of the neuron’s characteristic time scale, the result of action of HFS is defined by the ratio between the amplitude and the frequency of the stimulating signal. The effect of suppression emerges due to a stabilization of the neuron’s resting state or due to a stabilization of a low-amplitude subthreshold oscillation of its membrane potential. Intriguingly, although we neglect synaptic dynamics, neural circuity as well as contribution of glial cells, the results obtained with the isolated high-frequency stimulated STN model neuron resemble the clinically observed relations between stimulation amplitude and stimulation frequency required to suppress Parkinsonian tremor.
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影响因子：
168.9
作者：
LIMOUSIN, P;POLLAK, P;BENABID, AL
通讯作者：
BENABID, AL
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