Neural population-level memory traces in the mouse hippocampus.
Neural population-level memory traces in the mouse hippocampus.
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DOI：
10.1371/journal.pone.0008256
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发表时间：
2009-12-16
期刊：
影响因子：
3.7
通讯作者：
Tsien JZ
中科院分区：
文献类型：
--
作者：
Chen G;Wang LP;Tsien JZ
神经科学的基本目标之一是实时阐明大脑联想记忆痕迹的形成和提取。在这里，我们描述了小鼠海马CA 1区的实时神经系综瞬时动态，并展示了它们与学习和回忆期间行为表现的关系。我们采用了经典的微量恐惧条件反射范式，包括中性音调，然后在20秒后进行轻微的足部电击。我们的大规模记录和解码方法显示，条件性音调反应和音调休克关联模式不存在于CA 1在第一次配对，但出现后迅速多次配对。这些编码模式显示出增加的即时重放，与学习过程中增加的即时冻结密切相关。此外，在情境回忆过程中，这些模式每分钟重复出现6 ~ 14次，再次与行为回忆紧密相关。在跟踪音回忆，而各种恐惧记忆的检索，休克痕迹表现出一个独特的回忆峰周围的20秒的跟踪间隔，进一步标志着记忆的时间为预期的冲击。因此，我们的研究揭示了CA 1在学习和回忆过程中的各种实时联想记忆痕迹，并证明了实时记忆痕迹可以在任何单一试验中随时解码。
One of the fundamental goals in neurosciences is to elucidate the formation and retrieval of brain's associative memory traces in real-time. Here, we describe real-time neural ensemble transient dynamics in the mouse hippocampal CA1 region and demonstrate their relationships with behavioral performances during both learning and recall. We employed the classic trace fear conditioning paradigm involving a neutral tone followed by a mild foot-shock 20 seconds later. Our large-scale recording and decoding methods revealed that conditioned tone responses and tone-shock association patterns were not present in CA1 during the first pairing, but emerged quickly after multiple pairings. These encoding patterns showed increased immediate-replay, correlating tightly with increased immediate-freezing during learning. Moreover, during contextual recall, these patterns reappeared in tandem six-to-fourteen times per minute, again correlating tightly with behavioral recall. Upon traced tone recall, while various fear memories were retrieved, the shock traces exhibited a unique recall-peak around the 20-second trace interval, further signifying the memory of time for the expected shock. Therefore, our study has revealed various real-time associative memory traces during learning and recall in CA1, and demonstrates that real-time memory traces can be decoded on a moment-to-moment basis over any single trial.
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影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU
DOI：
10.1111/j.1460-9568.2008.06437.x
发表时间：
2008-10
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Hasselmo ME
通讯作者：
Hasselmo ME
影响因子：
56.9
作者：
BERRY, SD;THOMPSON, RF
通讯作者：
THOMPSON, RF
影响因子：
16.2
作者：
Csicsvari, J;Hirase, H;Buzsáki, G
通讯作者：
Buzsáki, G