Temporally structured replay of neural activity in a model of entorhinal cortex, hippocampus and postsubiculum.
Temporally structured replay of neural activity in a model of entorhinal cortex, hippocampus and postsubiculum.
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DOI：
10.1111/j.1460-9568.2008.06437.x
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Hasselmo ME
中科院分区：
文献类型：
--
作者：
Hasselmo ME
海马神经元在REM睡眠期间的尖峰活动表现出在先前经历的轨迹期间发生的尖峰的时间结构化重放。在这里，在REM睡眠期间的位置细胞活动的时间结构化重放建模在网格细胞，位置细胞和头部方向细胞的大规模网络模拟。在模拟清醒行为期间，模拟大鼠的运动驱动头部方向细胞群体的活动，该头部方向细胞群体更新内嗅网格细胞群体的活动。网格细胞的数量驱动着编码各个位置的位置细胞的活动。位置和运动方向之间的关联是通过从位置细胞到速度调制头方向细胞的兴奋性突触连接的修改来编码的。在模拟的快速眼动睡眠期间，编码体验位置的位置细胞群激活编码相关运动方向的头部方向细胞。然后，头部方向细胞的尖峰导致内嗅网格细胞群体内的频率偏移，以更新位置的相位表示。尖峰网格细胞然后激活新的位置细胞，驱动新的头部方向活动。与执行类似于尖波活动的时间压缩序列检索的模型相比，该模型可以模拟REM睡眠期间海马位置细胞活动的时间结构化重放数据，其时间尺度与清醒期间观察到的时间尺度相似。这些机制可能是重要的情节记忆的轨迹。
The spiking activity of hippocampal neurons during REM sleep exhibits temporally structured replay of spiking occurring during previously experienced trajectories. Here, temporally structured replay of place cell activity during REM sleep is modeled in a large-scale network simulation of grid cells, place cells and head direction cells. During simulated waking behavior, the movement of the simulated rat drives activity of a population of head direction cells that updates the activity of a population of entorhinal grid cells. The population of grid cells drives the activity of place cells coding individual locations. Associations between location and movement direction are encoded by modification of excitatory synaptic connections from place cells to speed modulated head direction cells. During simulated REM sleep, the population of place cells coding an experienced location activates the head direction cells coding the associated movement direction. Spiking of head direction cells then causes frequency shifts within the population of entorhinal grid cells to update a phase representation of location. Spiking grid cells then activate new place cells that drive new head direction activity. In contrast to models that perform temporally compressed sequence retrieval similar to sharp wave activity, this model can simulate data on temporally structured replay of hippocampal place cell activity during REM sleep at time scales similar to those observed during waking. These mechanisms could be important for episodic memory of trajectories.
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theta修饰的大鼠海马形成中的划分细胞。
DOI：
10.1523/jneurosci.2635-04.2004
发表时间：
2004-09-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cacucci F;Lever C;Wills TJ;Burgess N;O'Keefe J
通讯作者：
O'Keefe J
影响因子：
1.2
作者：
Franzius, M.;Vollgraf, R.;Wiskott, L.
通讯作者：
Wiskott, L.
影响因子：
3.5
作者：
Ainge, James A.;van der Meer, Matthijs A. A.;Wood, Emma R.
通讯作者：
Wood, Emma R.
影响因子：
1.9
作者：
Cho, JW;Sharp, PE
通讯作者：
Sharp, PE
影响因子：
3.5
作者：
Booth, V;Poe, GR
通讯作者：
Poe, GR