Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease.
Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease.
复制标题
DOI：
10.1007/s12350-014-0004-4
复制
发表时间：
2015-04
影响因子：
2.4
通讯作者：
Schulze, P. Christian
中科院分区：
文献类型：
--
作者：
Khawaja, Tuba;Greer, Christine;Thadani, Samir R.;Kato, Tomoko S.;Bhatia, Ketan;Shimbo, Daichi;Konkak, Andrew;Bokhari, Sabahat;Einstein, Andrew J.;Schulze, P. Christian
心外膜脂肪组织是促炎性细胞因子的来源，并与冠状动脉疾病的发展有关。没有研究系统地评估局部心外膜脂肪体积（EFV）和心肌灌注缺损之间的关系。我们分析了接受SPECT心肌灌注成像结合计算机断层扫描（CT）进行衰减校正的患者的EFV。对396例接受SPECT成像的连续患者进行了无造影剂低剂量CT检查，以评价冠状动脉疾病。评估区域厚度、横截面积和总EFV。295例患者心肌灌注扫描正常，101例患者心肌灌注扫描异常。正常、缺血和梗死心脏的平均EFV分别为99.8 ± 82.3 cm 3、156.4 ± 121.9 cm 3和96.3 ± 102.1 cm 3（P < 0.001）。与右冠状动脉（69.2 ± 51.5 vs 46.6 ± 32.0 cm 3; P = 0.03）和左冠状动脉前降支（87.1 ± 76.4 vs 46.7 ± 40.6 cm 3; P = 0.005）的正常灌注相比，可逆性灌注缺损与局部EFV增加相关。我们的研究结果表明，与心肌瘢痕或核灌注扫描正常灌注的患者相比，活动性心肌缺血患者的局部心外膜脂肪增加。我们的研究结果表明心脏CT在改善疑似冠心病患者的危险分层中具有潜在作用。
Epicardial adipose tissue is a source of pro-inflammatory cytokines and has been linked to the development of coronary artery disease. No study has systematically assessed the relationship between local epicardial fat volume (EFV) and myocardial perfusion defects. We analyzed EFV in patients undergoing SPECT myocardial perfusion imaging combined with computed tomography (CT) for attenuation correction. Low-dose CT without contrast was performed in 396 consecutive patients undergoing SPECT imaging for evaluation of coronary artery disease. Regional thickness, cross-sectional areas, and total EFV were assessed. 295 patients had normal myocardial perfusion scans and 101 had abnormal perfusion scans. Mean EFVs in normal, ischemic, and infarcted hearts were 99.8 ± 82.3 cm3, 156.4 ± 121.9 cm3, and 96.3 ± 102.1 cm3, respectively (P < 0.001). Reversible perfusion defects were associated with increased local EFV compared to normal perfusion in the distribution of the right (69.2 ± 51.5 vs 46.6 ± 32.0 cm3; P = 0.03) and left anterior descending coronary artery (87.1 ± 76.4 vs 46.7 ± 40.6 cm3; P = 0.005). Our results demonstrate increased regional epicardial fat in patients with active myocardial ischemia compared to patients with myocardial scar or normal perfusion on nuclear perfusion scans. Our results suggest a potential role for cardiac CT to improve risk stratification in patients with suspected coronary artery disease.
登录
查看更多内容
从对比增强的冠状动脉层析成像血管造影对心包脂肪组织的体积测量：一项可重复性研究。
影响因子：
5.4
作者：
Nichols, John H;Samy, Bharat;Nasir, Khurram;Fox, Caroline S;Schulze, P Christian;Bamberg, Fabian;Hoffmann, Udo
通讯作者：
Hoffmann, Udo
影响因子：
5.3
作者：
Gorter, Petra M.;van Lindert, Anne S. R.;Visseren, Frank L. J.
通讯作者：
Visseren, Frank L. J.
DOI：
10.1016/j.numecd.2008.05.002
发表时间：
2009-03-01
影响因子：
3.9
作者：
Eroglu, S.;Sade, L. E.;Muderrisoglu, H.
通讯作者：
Muderrisoglu, H.
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y
影响因子：
9.3
作者：
Baker, Adam R.;da Silva, Nancy F.;Quinn, David W.;Harte, Alison L.;Pagano, Domenico;Bonser, Robert S.;Kumar, Sudhesh;McTernan, Philip G.
通讯作者：
McTernan, Philip G.