Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans.
Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans.
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DOI：
10.1016/j.fct.2020.111695
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Park Y
中科院分区：
文献类型：
--
作者：
Yue Y;Li S;Qian Z;Pereira RF;Lee J;Doherty JJ;Zhang Z;Peng Y;Clark JM;Timme-Laragy AR;Park Y
全氟丁烷磺酸（PFBS）是全氟辛烷磺酸（PFOS）的同源短链全氟烷基和多氟烷基物质（PFASs），已被用作有毒表面活性剂全氟辛烷磺酸的替代品。然而，新出现的证据表明，PFBS的安全性问题及其对生殖健康的影响仍未得到充分研究。因此，本研究旨在以秀丽隐杆线虫为体内动物模型，研究PFBS对生殖健康的影响，并与PFOS进行比较。PFOS（≥10 μM）和PFBS（≥1000 μM）显著降低了线虫的繁殖能力，表现为降低了线虫的卵数（总卵数）和子代数（孵化后代数），但不影响线虫的孵化率。此外，孕前暴露于PFOS和PFBS显著改变了胚胎营养负荷和成分，从而导致F1后代生长速度、体型和运动活性的异常。虽然全氟辛烷磺酸的有效暴露浓度约为全氟辛烷磺酸的100倍，但要产生与全氟辛烷磺酸相似的效应，全氟辛烷磺酸的体内浓度要低于全氟辛烷磺酸。综上所述，全氟辛烷磺酸和全氟苯磺酸显著损害秀丽隐杆线虫的生殖能力，孕前接触这两种化合物可导致后代生理功能障碍。
Perfluorobutanesulfonic acid (PFBS), a shorter chain Per- and polyfluoroalkyl substances (PFASs) cognate of perfluorooctanesulfonic acid (PFOS), has been used as replacement for the toxic surfactant PFOS. However, emerging evidences suggest safety concerns for PFBS and its effect on reproductive health is still understudied. Therefore, the current work aimed to investigate the effect of PFBS, in comparison to PFOS, on reproductive health using Caenorhabditis elegans as an in vivo animal model. PFOS (≥ 10 μM) and PFBS (≥ 1000 μM) significantly impaired the reproduction capacity of C. elegans, represented as reduced brood size (total egg number) and progeny number (hatched offspring number), without affecting the hatchability. Additionally, the preconception exposure of PFOS and PFBS significantly altered the embryonic nutrient loading and composition, which further led to abnormalities in growth rate, body size and locomotive activity in F1 offspring. Though the effective exposure concentration of PFBS was approximately 100 times higher than PFOS, the internal concentration of PFBS was lower than that of PFOS to produce the similar effects of PFOS. In conclusion, PFOS and PFBS significantly impaired the reproductive capacities in C. elegans and the preconception exposure of these two compounds can lead to offspring physiological dysfunctions.
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