Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke.
Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke.
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DOI：
10.1016/j.yhbeh.2012.04.007
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发表时间：
2013-02
影响因子：
3.5
通讯作者：
McCullough, Louise D.
中科院分区：
文献类型：
--
作者：
Ritzel, Rodney M.;Capozzi, Lori A.;McCullough, Louise D.
关键词：
中风是发达国家第三大死亡原因和残疾的主要原因。实验和临床数据表明，中风是一种性别二态性疾病，男性在其一生的大部分时间里表现出对缺血性损伤的内在敏感性增强。雌激素在女性大脑中的神经保护作用已得到充分证实，然而，暴露于雌激素也可能是有害的，特别是对于老年女性。其机制尚不清楚。我们目前的理解是基于研究雌激素与神经元损伤的关系，但脑缺血也会诱发涉及局部和全身免疫细胞的强烈无菌炎症反应。尽管雌激素具有强大的抗炎作用，但很少有研究调查雌激素对中风炎症反应性别差异的影响。本综述探讨了雌激素介导的免疫保护在缺血性损伤中的潜在作用。
Stroke is the third leading cause of death and the primary cause of disability in the developed world. Experimental and clinical data indicate that stroke is a sexually dimorphic disease, with males demonstrating an enhanced intrinsic sensitivity to ischemic damage throughout most of their lifespan. The neuroprotective role of estrogen in the female brain is well established, however, estrogen exposure can also be deleterious, especially in older women. The mechanisms for this remain unclear. Our current understanding is based on studies examining estrogen as it relates to neuronal injury, yet cerebral ischemia also induces a robust sterile inflammatory response involving local and systemic immune cells. Despite the potent anti-inflammatory effects of estrogen, few studies have investigated the contribution of estrogen to sex differences in the inflammatory response to stroke. This review examines the potential role for estrogen-mediated immunoprotection in ischemic injury.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
影响因子：
30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
通讯作者：
Bentwich, Z
影响因子：
--
作者：
Adamski, J;Ma, ZD;Benveniste, EN
通讯作者：
Benveniste, EN
影响因子：
3.5
作者：
Arnold AP
通讯作者：
Arnold AP