Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes.
Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes.
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DOI：
10.1038/s41467-021-25443-4
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发表时间：
2021-09-02
影响因子：
16.6
通讯作者：
Meister M
中科院分区：
文献类型：
--
作者：
Lee KH;Ni YL;Colonell J;Karsh B;Putzeys J;Pachitariu M;Harris TD;Meister M
用于神经元电记录的最先进的硅探针有数千个记录位点。然而，由于体积限制，从探头传输信号的电线通常要少得多，这限制了可以同时记录的通道数量。为了克服这一基本限制，我们提出了一种称为电极池的方法，该方法使用单根电线通过一组可控开关为许多记录站点提供服务。在这里，我们介绍了该方法背后的框架以及支持它的实验策略。然后，我们通过在 Neuropixels 1.0 电极阵列上实施电极池并表征其对信号和噪声的影响来证明其可行性。最后，我们使用模拟来探索电极池在不影响记录内容的情况下节省电线的条件。我们对未来设备的设计提出建议，以利用这一策略。用于从神经元进行电记录的硅探针通常比可用于从探针传送信号的记录通道具有更少的电线，这限制了可以同时记录的通道数量。作者建议汇集电极，使用单根电线通过一组可控开关为多个通道提供服务。
State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying signals off the probe, which restricts the number of channels that can be recorded simultaneously. To overcome this fundamental constraint, we propose a method called electrode pooling that uses a single wire to serve many recording sites through a set of controllable switches. Here we present the framework behind this method and an experimental strategy to support it. We then demonstrate its feasibility by implementing electrode pooling on the Neuropixels 1.0 electrode array and characterizing its effect on signal and noise. Finally we use simulations to explore the conditions under which electrode pooling saves wires without compromising the content of the recordings. We make recommendations on the design of future devices to take advantage of this strategy. Silicon probes for electrical recording from neurons usually have fewer wires than recording channels available to carry signals off the probe, which restricts the number of channels that can be recorded simultaneously. The authors propose to pool electrodes, using a single wire to serve many channels through a set of controllable switches.
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影响因子：
4.3
作者：
Obien ME;Deligkaris K;Bullmann T;Bakkum DJ;Frey U
通讯作者：
Frey U
DOI：
10.1039/c5tb00108k
发表时间：
2015-07-07
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Kozai TD;Vazquez AL
通讯作者：
Vazquez AL
影响因子：
3
作者：
Barnett, Alex H.;Magland, Jeremy F.;Greengard, Leslie F.
通讯作者：
Greengard, Leslie F.
影响因子：
2.7
作者：
Seidl, Karsten;Schwaerzle, Michael;Ruther, Patrick
通讯作者：
Ruther, Patrick
纳米制作的神经探针，用于致密的3D记录脑活动。
影响因子：
10.8
作者：
Rios, Gustavo;Lubenov, Evguenqr V.;Chi, Derrick;Roukes, Michael L.;Siapas, Athanassios G.
通讯作者：
Siapas, Athanassios G.