Preparation of composite tubular grafts for vascular repair via electrospinning
Preparation of composite tubular grafts for vascular repair via electrospinning
复制标题
静电纺丝血管修复用复合管状移植物的制备
DOI：
10.1016/j.pnsc.2012.03.005
复制
发表时间：
2012-04
影响因子：
4.7
通讯作者：
El-Newehy, Mohamed
中科院分区：
文献类型：
--
作者：
Huang, Chen;Geng, Xiaohua;Ke, Qinfei;Mo, Xiumei;Al-Deyab, Salem S.;El-Newehy, Mohamed
本研究利用静电纺丝技术制备了一种新型的复合血管移植物。胶原蛋白和壳聚糖共混形成内层和外层。选择聚（L-丙交酯-co-己内酯）（P（LLA-CL））作为复合血管移植物的中间层材料。用扫描电镜（SEM）观察复合移植物的形态和直径。力学性能测试结果表明，与共混支架相比，复合支架具有更好的强度和柔韧性，这主要是由于中间层为P（LLA-CL）。内皮细胞的细胞活力研究表明，由于外层是胶原和壳聚糖，因此内皮细胞迅速粘附和增殖。共聚焦显微镜观察显示，培养7天后可形成单层内皮细胞。上述结果表明，该复合纤维支架是一种很好的血管修复材料。
A novel type of composite vascular graft was developed via electrospinning in the present investigation. Collagen and chitosan were blended to form the inner and outer layer. Poly(l-lactide-co-caprolactone) (P(LLA-CL)) was selected as a material for the middle layer of composite vascular graft. Both morphology and diameter of the composite grafts were studied by Scanning Electron Microscope (SEM). The results of mechanical tests showed that the composite scaffolds provided the whole grafts with better strength and flexibility compared with blended grafts, mainly due to the fact that the middle layer was P(LLA-CL). Cell viability studies with endothelial cells suggested a prompt adhesion and proliferation duo to the fact that the outer layer was collagen and chitosan. Confocal microscopy demonstrated that a monolayer of endothelial cells could be formed after 7 days of culture. The above results indicated that the composite fibrous scaffolds could be a good candidate for blood vessel repair by electrospinning method.
登录
查看更多内容
DOI：
10.1002/jbm.a.31567
发表时间：
2008-08
期刊：
Journal of biomedical materials research. Part A
影响因子：
--
作者：
A. Zhu;F. Zhao;Ning Fang
通讯作者：
A. Zhu;F. Zhao;Ning Fang
影响因子：
6.2
作者：
Sarah Weisman;H. Trueman;S. Mudie;J. Church;T. Sutherland;V. Haritos
通讯作者：
Sarah Weisman;H. Trueman;S. Mudie;J. Church;T. Sutherland;V. Haritos
DOI：
10.1016/j.pnsc.2011.12.010
发表时间：
2012-02
期刊：
Progress in Natural Science: Materials International
影响因子：
--
作者：
Delong Li;C. Pan
通讯作者：
Delong Li;C. Pan
影响因子：
56.9
作者：
M. Stevens;Julian H. George
通讯作者：
M. Stevens;Julian H. George
影响因子：
4.9
作者：
Cao, Yang;Zhang, Bing;Cooper-White, Justin J.
通讯作者：
Cooper-White, Justin J.