Cortical Morphological Changes in Congenital Amusia: Surface-Based Analyses.
Cortical Morphological Changes in Congenital Amusia: Surface-Based Analyses.
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先天性失乐症的皮质形态变化：基于表面的分析
DOI：
10.3389/fpsyt.2021.721720
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发表时间：
2021
影响因子：
4.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Liao X;Sun J;Jin Z;Wu D;Liu J
背景资料：先天性失听症（CA）是一种罕见的疾病，其特征是音高感知缺陷，许多结构和功能磁共振成像研究已进行，以更好地了解其神经基础。然而，结构磁共振成像分析，使用基于表面的形态学方法，以确定在基于顶点的水平与皮质特征异常的区域尚未执行。方法：15例CA患者和13例健康对照者进行结构磁共振成像。基于表面的形态学方法用于识别解剖异常。然后，提取并比较具有统计学显著组间差异的识别出的簇的表面参数的平均值。最后，Pearson相关分析用于评估蒙特利尔Amusia评估组合（MBEA）评分和表面参数之间的相关性。结果：CA组的MBEA评分显著低于健康对照组（p = 0.000）。与健康对照组相比，CA组在右侧尾侧额中回中表现出显著更高的分形维数，而在右侧三角部回中表现出更低的沟深度（p < 0.05;在聚类水平上校正的错误发现率）。右侧额中尾侧回的平均分维值与MBEA评分呈负相关，包括平均MBEA评分（r =-0.5398，p = 0.0030），量表评分（r =-0.5712，p = 0.0015），轮廓评分（r =-0.4662，p = 0.0124），区间评分（r =-0.4564，p = 0.0146）、节奏评分（r =-0.5133，p = 0.0052）、节拍评分（r =-0.3937，p = 0.0382）和记忆评分（r =-0.3879，p = 0.0414）。右侧三角回平均沟深与MBEA评分呈显著正相关，（r = 0.5130，p = 0.0052），量表评分（r = 0.5328，p = 0.0035），区间评分（r = 0.4059，p = 0.0321）、节奏评分（r = 0.5733，p = 0.0014）、节拍评分（r = 0.5061，p = 0.0060）和记忆评分（r = 0.4001，p = 0.0349）。结论：CA患者右半球皮质形态学改变。这些发现可能表明，在个人与CA的言语知觉和记忆障碍的神经基础与异常的右侧三角回和额中回，这些皮质异常可能是CA的神经标记。
Background: Congenital amusia (CA) is a rare disorder characterized by deficits in pitch perception, and many structural and functional magnetic resonance imaging studies have been conducted to better understand its neural bases. However, a structural magnetic resonance imaging analysis using a surface-based morphology method to identify regions with cortical features abnormalities at the vertex-based level has not yet been performed. Methods: Fifteen participants with CA and 13 healthy controls underwent structural magnetic resonance imaging. A surface-based morphology method was used to identify anatomical abnormalities. Then, the surface parameters' mean value of the identified clusters with statistically significant between-group differences were extracted and compared. Finally, Pearson's correlation analysis was used to assess the correlation between the Montreal Battery of Evaluation of Amusia (MBEA) scores and surface parameters. Results: The CA group had significantly lower MBEA scores than the healthy controls (p = 0.000). The CA group exhibited a significant higher fractal dimension in the right caudal middle frontal gyrus and a lower sulcal depth in the right pars triangularis gyrus (p < 0.05; false discovery rate-corrected at the cluster level) compared to healthy controls. There were negative correlations between the mean fractal dimension values in the right caudal middle frontal gyrus and MBEA score, including the mean MBEA score (r = −0.5398, p = 0.0030), scale score (r = −0.5712, p = 0.0015), contour score (r = −0.4662, p = 0.0124), interval score (r = −0.4564, p = 0.0146), rhythmic score (r = −0.5133, p = 0.0052), meter score (r = −0.3937, p = 0.0382), and memory score (r = −0.3879, p = 0.0414). There was a significant positive correlation between the mean sulcal depth in the right pars triangularis gyrus and the MBEA score, including the mean score (r = 0.5130, p = 0.0052), scale score (r = 0.5328, p = 0.0035), interval score (r = 0.4059, p = 0.0321), rhythmic score (r = 0.5733, p = 0.0014), meter score (r = 0.5061, p = 0.0060), and memory score (r = 0.4001, p = 0.0349). Conclusion: Individuals with CA exhibit cortical morphological changes in the right hemisphere. These findings may indicate that the neural basis of speech perception and memory impairments in individuals with CA is associated with abnormalities in the right pars triangularis gyrus and middle frontal gyrus, and that these cortical abnormalities may be a neural marker of CA.
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影响因子：
2.6
作者：
Corrow, Sherryse L.;Stubbs, Jacob L.;Schlaug, Gottfried;Buss, Stephanie;Paquette, Sebastien;Duchaine, Brad;Barton, Jason J. S.
通讯作者：
Barton, Jason J. S.
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作者：
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通讯作者：
Peretz, Isabelle
影响因子：
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作者：
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面部识别受损与先天性失乐症后扣带皮层灰质体积异常有关
影响因子：
2.6
作者：
Jin, Zhishuai;Lu, Xuejing;Wu, Daxing
通讯作者：
Wu, Daxing