Childhood maltreatment and combat posttraumatic stress differentially predict fear-related fronto-subcortical connectivity.
Childhood maltreatment and combat posttraumatic stress differentially predict fear-related fronto-subcortical connectivity.
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DOI：
10.1002/da.22291
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发表时间：
2014-10
影响因子：
7.4
通讯作者：
Herringa, Ryan J.
中科院分区：
文献类型：
--
作者：
Birn, Rasmus M.;Patriat, Remi;Phillips, Mary L.;Germain, Anne;Herringa, Ryan J.
成人创伤后应激障碍（PTSD）以恐惧网络连接改变为特征。童年创伤是成人PTSD的主要危险因素，但其对PTSD中恐惧网络连接的影响尚不清楚。在单一模型中，我们检验了童年虐待、战斗暴露和与战斗相关的创伤后应激症状（PTSS）对退伍军人杏仁核和海马体静息状态连通性（rs-FC）的贡献。无药物治疗的男性退伍军人（n=27，平均26.6岁），PTSS范围完成静息状态fMRI。采用临床创伤后应激障碍量表（CAPS）、儿童创伤问卷（CTQ）和战斗暴露量表（CES）等方法，采用多元线性回归预测rs-FC。恐惧网络种子包括杏仁核和海马体。杏仁核：CTQ预测与腹内侧前额叶皮质（vmPFC）的连通性较低，但与背侧/外侧PFC的负相关更大。CAPS正预测与岛的连通性，以及与背内侧/背外侧PFC （dm/dl）的负相关丧失。CTQ预测与vmPFC的连通性较低，但与dm/dlPFC的反相关性较大。CES预测与dmPFC的反相关更大，而CAPS预测与dmPFC的反相关较小。童年创伤、战斗暴露和创伤后应激障碍对恐惧网络rs-FC的预测存在差异。儿童期虐待可能会削弱在自动恐惧调节中很重要的腹侧前额叶-皮层下回路，但是，以一种代偿方式，也可能会加强参与更努力的情绪调节的背侧前额叶-皮层下通路。创伤后应激障碍的症状，反过来，似乎随着后一途径的连通性的丧失而出现。这些发现提示了发育性创伤暴露导致成人PTSD的潜在机制，以及哪些脑机制与PTSD症状的出现有关。
Adult post-traumatic stress disorder (PTSD) has been characterized by altered fear network connectivity. Childhood trauma is a major risk factor for adult PTSD, yet its contribution to fear network connectivity in PTSD remains unexplored. We examined, within a single model, the contribution of childhood maltreatment, combat exposure, and combat-related post-traumatic stress symptoms (PTSS) to resting-state connectivity (rs-FC) of the amygdala and hippocampus in military veterans. Medication-free male veterans (n=27, average 26.6 years) with a range of PTSS completed resting-state fMRI. Measures including the Clinician-Administered PTSD Scale (CAPS), Childhood Trauma Questionnaire (CTQ), and Combat Exposure Scale (CES) were used to predict rs-FC using multi-linear regression. Fear network seeds included the amygdala and hippocampus. Amygdala: CTQ predicted lower connectivity to ventromedial prefrontal cortex (vmPFC), but greater anticorrelation with dorsal/lateral PFC. CAPS positively predicted connectivity to insula, and loss of anticorrelation with dorsomedial/dorsolateral (dm/dl)PFC. CTQ predicted lower connectivity to vmPFC, but greater anticorrelation with dm/dlPFC. CES predicted greater anticorrelation, while CAPS predicted less anticorrelation with dmPFC. Childhood trauma, combat exposure, and PTSS differentially predict fear network rs-FC. Childhood maltreatment may weaken ventral prefrontal-subcortical circuitry important in automatic fear regulation, but, in a compensatory manner, may also strengthen dorsal prefrontal-subcortical pathways involved in more effortful emotion regulation. PTSD symptoms, in turn, appear to emerge with the loss of connectivity in the latter pathway. These findings suggest potential mechanisms by which developmental trauma exposure leads to adult PTSD, and which brain mechanisms are associated with the emergence of PTSD symptoms.
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DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
--
作者：
Jo HJ;Gotts SJ;Reynolds RC;Bandettini PA;Martin A;Cox RW;Saad ZS
通讯作者：
Saad ZS
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
6.9
作者：
Herringa, R. J.;Phillips, M. L.;Fournier, J. C.;Kronhaus, D. M.;Germain, A.
通讯作者：
Germain, A.
影响因子：
6.9
作者：
Cisler, J. M.;James, G. A.;Kilts, C. D.
通讯作者：
Kilts, C. D.