Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.
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DOI：
10.1126/science.1164901
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发表时间：
2009-03-20
期刊：
影响因子：
--
通讯作者：
Nicolelis MA
中科院分区：
文献类型：
--
作者：
Fuentes R;Petersson P;Siesser WB;Caron MG;Nicolelis MA
多巴胺替代疗法对治疗帕金森病早期的运动症状是有用的，但长期效果不佳。脑深部电刺激是药物治疗的一种有价值的补充，但涉及高度侵入性的外科手术。我们发现，在脊髓背柱的硬膜外电刺激恢复运动在急性多巴胺诱导的小鼠和慢性6-羟基多巴胺损伤的大鼠。异常低频同步皮质纹状体振荡的中断，导致神经元活动模式的出现，类似于正常自发启动运动之前的状态。我们建议，背柱刺激可能成为一个有效的和微创的替代治疗帕金森氏病的未来。
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson’s disease, but is less effective in the long-term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson’s disease in the future.
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