Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy.

Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy.
复制标题

DOI:
10.3390/molecules190913803
复制
发表时间:
2014-09-03
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Keller A
Keller A
中科院分区:
其他
文献类型:
--
作者:
Bald I;Keller A

文献摘要

参考文献

被引文献

相似文献

DNA折纸纳米结构允许以前所未有的精确度排列不同的功能,例如蛋白质、特定的DNA结构、纳米颗粒和各种化学修饰。排列的功能实体可以通过原子力显微镜(AFM)可视化,这使得能够在单分子水平上研究分子过程。例子包括化学反应,电子诱导的键断裂,酶结合和切割事件,以及DNA中的构象转变的研究。在本文中,我们提供了一个概述的单分子研究领域取得的进展,通过应用原子力显微镜功能化的DNA折纸基板。
DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
DOI: 10.1038/ncomms1452
发表时间: 2011-08-23
影响因子: 16.6
作者:
通讯作者: --
DOI: 10.1126/science.1228638
发表时间: 2012-10-26
期刊: SCIENCE
影响因子: 56.9
作者:
Acuna, G. P.;Moeller, F. M.;Tinnefeld, P.
通讯作者: Tinnefeld, P.
DOI: 10.1021/nn2050483
发表时间: 2012-04-01
期刊: ACS NANO
影响因子: 17.1
作者:
Acuna, Guillermo P.;Bucher, Martina;Tinnefeld, Philip
通讯作者: Tinnefeld, Philip
DOI: 10.1021/nn3010747
发表时间: 2012-05-01
期刊: ACS NANO
影响因子: 17.1
作者:
Keller, Adrian;Bald, Ilko;Besenbacher, Flemming
通讯作者: Besenbacher, Flemming
DOI: 10.1021/nn102701f
发表时间: 2010-12-01
期刊: ACS NANO
影响因子: 17.1
作者:
Helmig, Sarah;Rotaru, Alexandru;Gothelf, Kurt V.
通讯作者: Gothelf, Kurt V.