Activation of mucosal immunity as a novel therapeutic strategy for combating brucellosis.
Activation of mucosal immunity as a novel therapeutic strategy for combating brucellosis.
复制标题
DOI：
10.3389/fmicb.2022.1018165
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Yang, Xinghong
中科院分区：
文献类型：
--
作者：
Pascual, David W.;Goodwin, Zakia I.;Bhagyaraj, Ella;Hoffman, Carol;Yang, Xinghong
关键词：
布鲁氏菌病是一种家畜疾病，在发生流产之前通常没有症状。人类疾病是由接触受感染的牲畜或食用受污染的牛奶或肉类引起的。人畜共患病布鲁氏菌主要由感染牲畜的三种物种之一引起，即牛的流产芽孢杆菌、山羊和绵羊的布鲁氏菌以及猪的猪布鲁氏菌。为了帮助预防疾病，可以使用牲畜疫苗，但只有 70% 有效率；因此，需要改进疫苗来减轻疾病，特别是在疾病仍然普遍存在的国家。由于不知道哪些蛋白质能提供完全保护，限制了亚单位疫苗的开发。相反，人们的努力重点是开发新的和改进的减毒活布鲁氏菌疫苗，因为这些疫苗模仿野生型布鲁氏菌的特性，并刺激宿主免疫，特别是保护所需的 T 辅助 1 型反应。在考虑其发展时，新突变体必须解决布鲁氏菌通常活跃的防御机制，以规避宿主免疫检测。疫苗接种方法还应考虑传递方式和途径，因为牲畜和人类之间的疾病传播被认为是通过鼻口咽组织发生的。通过用常驻记忆 T 细胞 (TRM) 武装宿主的粘膜免疫防御系统并扩大 IFN-γ 的来源，可以防止布鲁氏菌从感染部位传播到全身组织。在这篇综述中，讨论的重点是了解疾病进展中涉及的各种免疫机制，以及哪些免疫参与者在对抗疾病中发挥着重要作用。
Brucellosis is a disease of livestock that is commonly asymptomatic until an abortion occurs. Disease in humans results from contact of infected livestock or consumption of contaminated milk or meat. Brucella zoonosis is primarily caused by one of three species that infect livestock, Bacillus abortus in cattle, B. melitensis in goats and sheep, and B. suis in pigs. To aid in disease prophylaxis, livestock vaccines are available, but are only 70% effective; hence, improved vaccines are needed to mitigate disease, particularly in countries where disease remains pervasive. The absence of knowing which proteins confer complete protection limits development of subunit vaccines. Instead, efforts are focused on developing new and improved live, attenuated Brucella vaccines, since these mimic attributes of wild-type Brucella, and stimulate host immune, particularly T helper 1-type responses, required for protection. In considering their development, the new mutants must address Brucella’s defense mechanisms normally active to circumvent host immune detection. Vaccination approaches should also consider mode and route of delivery since disease transmission among livestock and humans is believed to occur via the naso-oropharyngeal tissues. By arming the host’s mucosal immune defenses with resident memory T cells (TRMs) and by expanding the sources of IFN-γ, brucellae dissemination from the site of infection to systemic tissues can be prevented. In this review, points of discussion focus on understanding the various immune mechanisms involved in disease progression and which immune players are important in fighting disease.
登录
查看更多内容
影响因子：
1.3
作者：
Arenas-Gamboa, Angela M.;Ficht, Thomas A.;Rice-Ficht, Allison C.
通讯作者：
Rice-Ficht, Allison C.
影响因子：
3.1
作者：
Barrionuevo, Paula;Cassataro, Juliana;Giambartolomei, Guillermo H.
通讯作者：
Giambartolomei, Guillermo H.
影响因子：
5.5
作者：
BOSSERAY, N;PLOMMET, M
通讯作者：
PLOMMET, M
影响因子：
3.1
作者：
BRATESCU, A;MAYER, EP;TEODORESCU, M
通讯作者：
TEODORESCU, M
在21世纪治疗布鲁氏菌病的观点：ioannina的建议。
影响因子：
15.8
作者：
Ariza J;Bosilkovski M;Cascio A;Colmenero JD;Corbel MJ;Falagas ME;Memish ZA;Roushan MR;Rubinstein E;Sipsas NV;Solera J;Young EJ;Pappas G;International Society of Chemotherapy;Institute of Continuing Medical Education of Ioannina
通讯作者：
Institute of Continuing Medical Education of Ioannina