Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery.
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery.
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DOI：
10.1007/s12274-009-9009-8
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发表时间：
2009-02-01
期刊：
影响因子：
9.9
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Liu, Zhuang;Tabakman, Scott;Welsher, Kevin;Dai, Hongjie
关键词：
碳纳米管具有许多独特的物理和化学性质，在过去的几年中，已经被广泛地探索用于生物和生物医学应用。在这篇全面的综述中，我们总结了我们和其他小组在这一领域的主要成果，并阐明了表面官能化对碳纳米管在生物系统中的行为至关重要。通过对碳纳米管表面进行钝化处理，抑制生物分子在疏水性纳米管表面的非特异性结合，可以实现碳纳米管对生物物种的超灵敏检测。基于纳米管的电纳米传感器提供了一种无标记的生物检测方法。碳纳米管的表面增强拉曼光谱开辟了一种检测灵敏度低至1 fmol/L的蛋白质微阵列方法。体外和体内毒性研究表明，高水溶性和血清稳定的纳米管是生物相容的，无毒的，并有潜在的生物医学应用。体内生物分布随功能化和可能的纳米管尺寸而变化，静脉内给药后有在网状内皮系统（RES）（包括肝脏和脾脏）中蓄积的趋势。如果功能化良好，则纳米管可以主要通过粪便中的胆道途径排出。基于碳纳米管的药物递送已经在各种体外和体内实验中显示出前景，包括递送小干扰RNA（siRNA）、紫杉醇和多柔比星。此外，单壁碳纳米管具有各种有趣的固有光学特性，已被用作新型光致发光，拉曼，和光声造影剂的细胞和动物的成像。在这一领域的进一步多学科探索可能会在生物医学领域带来新的机遇。
Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years. In this comprehensive review, we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological systems. Ultrasensitive detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube surface. Electrical nanosensors based on nanotubes provide a label-free approach to biological detection. Surface-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/L. In vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible, nontoxic, and potentially useful for biomedical applications. In vivo biodistributions vary with the functionalization and possibly also size of nanotubes, with a tendency to accumulate in the reticuloendothelial system (RES), including the liver and spleen, after intravenous administration. If well functionalized, nanotubes may be excreted mainly through the biliary pathway in feces. Carbon nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA (siRNA), paclitaxel and doxorubicin. Moreover, single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence, Raman, and photoacoustic contrast agents for imaging of cells and animals. Further multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine.
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影响因子：
3.2
作者：
Chin, Shook-Fong;Baughman, Ray H.;Pantano, Paul
通讯作者：
Pantano, Paul
影响因子：
15
作者：
Crochet, Jared;Clemens, Michael;Hertel, Tobias
通讯作者：
Hertel, Tobias
影响因子：
4.9
作者：
Bianco, A;Kostarelos, K;Prato, M
通讯作者：
Prato, M
DOI：
10.1073/pnas.0837064100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Chen, RJ;Bangsaruntip, S;Dai, HJ
通讯作者：
Dai, HJ
影响因子：
46.9
作者：
Choi, Hak Soo;Liu, Wenhao;Frangioni, John V.
通讯作者：
Frangioni, John V.