Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.
Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.
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DOI：
10.1021/acs.chemrev.1c00009
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发表时间：
2021-07-14
期刊：
影响因子：
62.1
通讯作者：
Guo P
中科院分区：
文献类型：
--
作者：
Binzel DW;Li X;Burns N;Khan E;Lee WJ;Chen LC;Ellipilli S;Miles W;Ho YS;Guo P
RNA纳米技术是自下而上的纳米级结构的自组装，类似于LEMPERATURE，主要由RNA组成。理想的构建材料应该是（1）形状和化学计量的通用和可控，（2）自发自组装，和（3）具有长保质期的药物，化学和酶稳定性。RNA构建块表现出上述每一种。RNA是一种多核酸，使其成为一种聚合物，并且其负电荷防止与带负电荷的细胞膜非特异性结合。热稳定性使其适用于逻辑门、电阻存储器、传感器设置和NEM器件。RNA可以被设计和操作，具有DNA的简单性，同时显示蛋白质的多功能结构和酶活性。RNA可以折叠成单链环或凸起，作为分子间相互作用或结构域相互作用的安装燕尾，而无需外部连接销钉。RNA纳米颗粒显示出橡胶和变形虫样的特性，并且通过多次重复可拉伸和收缩，从而增强肿瘤靶向和快速肾排泄以减少毒性。2014年，有人预测RNA将成为药物开发的第三个里程碑。FDA最近批准了几种RNA药物和COVID-19 mRNA疫苗，表明这一里程碑正在实现。在这里，我们回顾了RNA纳米技术的独特性质，总结了它的最新进展，描述了它在体内或体外的独特属性，并讨论了在纳米技术，医学和材料科学中的潜在应用。
RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures, resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) versatile and controllable in shape and stoichiometry, (2) spontaneously self-assemble, and (3) thermodynamically, chemically, and enzymatically stable with a long shelf life. RNA building blocks exhibit each of the above. RNA is a polynucleic acid, making it a polymer, and its negative-charge prevents nonspecific binding to negatively charged cell membranes. The thermostability makes it suitable for logic gates, resistive memory, sensor set-ups, and NEM devices. RNA can be designed and manipulated with a level of simplicity of DNA while displaying versatile structure and enzyme activity of proteins. RNA can fold into single-stranded loops or bulges to serve as mounting dovetails for intermolecular or domain interactions without external linking dowels. RNA nanoparticles display rubber- and amoeba-like properties and are stretchable and shrinkable through multiple repeats, leading to enhanced tumor targeting and fast renal excretion to reduce toxicities. It was predicted in 2014 that RNA would be the third milestone in pharmaceutical drug development. The recent approval of several RNA drugs and COVID-19 mRNA vaccines by FDA suggests that this milestone is being realized. Here, we review the unique properties of RNA nanotechnology, summarize its recent advancements, describe its distinct attributes inside or outside the body and discuss potential applications in nanotechnology, medicine, and material science.
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影响因子：
13.3
作者：
Alhasan, Ali H.;Patel, Pinal C.;Choi, Chung Hang J.;Mirkin, Chad A.
通讯作者：
Mirkin, Chad A.
基于氨基接头的插入，在特定RNA位置引入各种化学标签的一般方法。
DOI：
10.3390/molecules181214455
发表时间：
2013-11-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Graifer D;Karpova G
通讯作者：
Karpova G
影响因子：
38.3
作者：
通讯作者：
--
DOI：
10.1261/rna.063453.117
发表时间：
2017-12
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Ashraf S;Huang L;Lilley DMJ
通讯作者：
Lilley DMJ
影响因子：
12.4
作者：
Abdelmawla, Sherine;Guo, Songchuan;Li, Qi-Xiang
通讯作者：
Li, Qi-Xiang