Birth weight effects on children's mental, motor, and physical development: evidence from twins data.
Birth weight effects on children's mental, motor, and physical development: evidence from twins data.
复制标题
DOI：
10.1007/s10995-009-0461-6
复制
发表时间：
2009-11
影响因子：
2.3
通讯作者：
Jacknowitz A
中科院分区：
文献类型：
--
作者：
Datar A;Jacknowitz A
为了确定极低出生体重（VLBW；<1500g）和中低出生体重（MLBW；1500-2499g）对儿童生命头两年的智力和运动发育以及身体生长的影响，以及VLBW和MLBW婴儿在2岁时是否赶上正常出生体重（NBW；> = 2500g）儿童。我们使用双卵（DZ）和同卵（MZ）的数据早期儿童纵向研究 – 出生队列 (ECLS-B) 是 2001 年在美国出生的具有全国代表性的儿童数据集。我们评估了 VLBW 和 MLBW 对儿童 9 个月和 2 岁时智力和运动发育评分、年龄别体重、身长别体重、身高体重和年龄别身长 z 分数的影响。我们研究双胞胎的结果差异是否与其出生体重的差异有关。双胞胎内分析是对异卵双胞胎和同卵双胞胎的样本进行的。为了进行比较，我们还使用完整的单胎和双胞胎样本，通过多元线性回归模型估计了出生体重对儿童结局的影响。我们还使用同一组模型估计了小于胎龄（SGA；出生体重<妊娠第 10 个百分位）的影响，以便区分胎儿生长受限和早产的影响。对所有出生婴儿的评估表明，极低出生体重和极低出生体重对 9 个月和 2 岁时的智力发育、运动发育和生长有很大的负面影响。然而，控制了共同的母亲和环境因素的同卵双胞胎的同卵双胞胎内模型的结果显示，出生体重对智力或运动发育的影响要小得多，但对极低出生体重组的生长影响仍然很大。控制了共同的母亲、环境和遗传因素的同卵双胞胎的同卵双胞胎内模型显示，出生体重对智力和运动发育的影响在统计上不显着，但对生长的影响却持续存在。在检查 SGA 的影响时也发现了类似的模式。在控制了母体、环境和遗传因素的影响后，低出生体重对儿童头两年的智力和运动发育最多只会产生很小的负面影响。然而，低出生体重是儿童早期身体生长的一个主要风险因素，并且没有证据表明到 2 岁时会出现这种情况。
To determine the effect of very low birth weight (VLBW; <1500g) and moderately low birth weight (MLBW; 1500–2499g) on children’s mental and motor development and physical growth during the first two years of life and whether VLBW and MLBW babies catch up to normal birth weight (NBW; >=2500g) children by age 2. We use data on dizygotic (DZ) and monozygotic (MZ) twins and singleton births from the first two waves of the Early Childhood Longitudinal Study – Birth Cohort (ECLS-B), a nationally representative dataset of children born in the U.S. in 2001. We estimate the effects of VLBW and MLBW on children’s mental and motor development scores, weight-for-age, weight-for-length, weight-for-height, and length-for-age z-scores at 9 months and 2 years. We examine whether differences in outcomes within twin pairs are related to differences in their birth weights. The within-twins analysis is conducted on samples of DZ and MZ twins. For comparison, we also estimate birth weight effects on child outcomes from multivariate linear regression models using the full singleton and twins sample. We also estimate the effect of being small-for-gestational age (SGA; birth weight<10th percentile for gestation) using the same set of models in order to separate out the effects of fetal growth restriction from prematurity. Evaluation of all births showed that VLBW and MLBW have large negative effects on mental development, motor development, and growth at 9 months and 2 years of age. However, results from within-twin models with DZ twins that control for shared maternal and environmental factors showed much less effect of birth weight on mental or motor development, but continued large effects on growth for the VLBW group. Within-twin models with MZ twins that control for shared maternal, environmental, and genetic factors showed statistically insignificant effects of birth weight on mental and motor development, but continued effects on growth. Similar patterns were found when examining the effects of SGA. After controlling for the influence of maternal, environmental, and genetic factors, low birth weight has at most a small negative effect on children’s mental and motor development in their first two years of life. However, low birth weight is a major risk factor for children’s physical growth in the early years and there is no evidence of catch-up by age 2.
登录
查看更多内容
影响因子：
7.7
作者：
Iliadou, A;Cnattingius, S;Lichtenstein, P
通讯作者：
Lichtenstein, P
影响因子：
168.9
作者：
Hübinette, A;Cnattingius, S;Lichtenstein, P
通讯作者：
Lichtenstein, P
影响因子：
120.7
作者：
Hack, M;Taylor, HG;Klein, N
通讯作者：
Klein, N
影响因子：
4
作者：
Hall, JG
通讯作者：
Hall, JG
影响因子：
6.3
作者：
Christensen, K;Stovring, H;McGue, M
通讯作者：
McGue, M