Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes.
Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes.
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DOI：
10.2337/dc10-0811
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发表时间：
2010-11
期刊：
影响因子：
16.2
通讯作者：
Nelson RG
中科院分区：
文献类型：
--
作者：
Pavkov ME;Hanson RL;Knowler WC;Sievers ML;Bennett PH;Nelson RG
我们研究了宫内糖尿病暴露（IDE）对患有2型糖尿病的皮马印第安人糖尿病终末期肾病（ESRD）发病率的影响。个体从他们的第一次糖尿病检查一直随访到2006年12月，死亡，ESRD或45岁。在1,850名糖尿病患者中，102人患有IDE。57例发生ESRD，其中5例发生IDE。45岁时ESRD的累积发生率在IDE受试者中为19.3%，在未IDE受试者中为5.1%;年龄和性别校正的发生率比值为4.12（95% CI 1.54-11.02）。在对糖尿病发病时的年龄进行额外校正后，两组的ESRD发生率相似（发生率比1.38，95% CI 0.45-4.24）。IDE使年轻2型糖尿病患者的年龄和性别调整后的ESRD发病率增加4倍，主要是由IDE患者的2型糖尿病早期发作介导的。
We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54–11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45–4.24). IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.
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DOI：
10.1111/j.1471-0528.2008.01822.x
发表时间：
2008-09-01
影响因子：
5.8
作者：
Painter, R. C.;Osmond, C.;Roseboom, T. J.
通讯作者：
Roseboom, T. J.
影响因子：
7.7
作者：
Dabelea, D;Hanson, RL;Knowler, WC
通讯作者：
Knowler, WC
影响因子：
16.2
作者：
Burrows NR;Li Y;Geiss LS
通讯作者：
Geiss LS
影响因子：
7.7
作者：
PETTITT, DJ;ALECK, KA;KNOWLER, WC
通讯作者：
KNOWLER, WC
影响因子：
8.2
作者：
Dabelea, D;Hanson, RL;Pettitt, DJ
通讯作者：
Pettitt, DJ