Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice.
Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice.
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作者：
Yoshizaki Y;Kawasaki C;Cheng KC;Ushikai M;Amitani H;Asakawa A;Okutsu K;Sameshima Y;Takamine K;Inui A
米曲被认为是一种容易获得的功能食品，可能具有促进健康的作用。我们研究了白、黄、红曲对饲喂高脂饲料（HFD）的C57BL/6J小鼠是否具有抗肥胖作用。小鼠分别饲喂含10% （w/w）米曲粉或米饭的HFD 4周。4周后，各米曲组的增重、附睾白色脂肪组织和总脂肪组织重量均显著低于HFD-rice组。黄曲组饲料效率显著降低。白曲组和红曲组血糖水平显著降低，白曲组HOMA-R和瘦素水平降低。白曲和红曲增加了L6肌管细胞的葡萄糖摄取和GLUT4蛋白表达。这些结果表明，所有的米曲都具有抗肥胖或抗糖尿病的作用，但其作用机制可能因食用的米曲类型而异。
Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed.
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DOI：
10.1016/j.bbrc.2010.01.095
发表时间：
2010-02-26
影响因子：
3.1
作者：
Nagai, Ryoji;Nagai, Mime;Shimasaki, Satoko;Baynes, John W.;Fujiwara, Yukio
通讯作者：
Fujiwara, Yukio
影响因子：
4.1
作者：
KERN, M;WELLS, JA;DOHM, GL
通讯作者：
DOHM, GL
影响因子：
1.6
作者：
Miyake, Yoshiaki;Mochizuki, Mika;Osawa, Toshihiko
通讯作者：
Osawa, Toshihiko
影响因子：
6.1
作者：
Cheng, Chin-fu;Pan, Tzu-Ming
通讯作者：
Pan, Tzu-Ming
影响因子：
1.1
作者：
Trimarco, Bruno;Benvenuti, Claudio;Rozza, Francesco;Cimmino, Claudia Sara;Giudice, Renata;Crispo, Salvatore
通讯作者：
Crispo, Salvatore