Olfactory Exposure to β-Caryophyllene Increases Testosterone Levels in Women's Saliva
Olfactory Exposure to β-Caryophyllene Increases Testosterone Levels in Women's Saliva
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嗅觉暴露于 β-石竹烯会增加女性唾液中的睾酮水平
DOI：
10.1016/j.esxm.2020.06.001
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发表时间：
2020
期刊：
影响因子：
2.6
通讯作者：
Shinohara Kazuyuki
中科院分区：
文献类型：
--
作者：
Tarumi Wataru;Shinohara Kazuyuki
简介根据之前的研究，我们假设嗅觉暴露于 β-石竹烯会刺激女性的性欲。然而，日本的性文化是如此封闭，如果不积累科学证据，很难检验这种可能性。因此，有必要测量唾液中性相关激素的浓度，这是一种相对容易获得研究许可的实验技术，并获得说服伦理委员会审查者的科学依据。 目的本研究的目的是探讨β-石竹烯是否会增加女性性交过程中与性欲和阴道感觉相关的唾液睾酮浓度。方法19名处于卵泡期的女性 月经周期参与了这项研究。然后受试者坐在我们制作的气味暴露装置前。每个受试者接触二丙二醇 20 分钟，然后接触 3% β-石竹烯 20 分钟。收集唾液 4 次：对照暴露之前和之后，以及 β-石竹烯暴露之前和之后。主要结果测量通过竞争 ELISA 测量唾液睾酮和雌激素浓度。结果β-石竹烯显着增加唾液睾酮浓度（对照 vs β-石竹烯；0.97 ± 0.05 vs 1.13 ± 0.03，P= .00, 对照的 95% 置信区间：0.84–1.09，β-石竹烯的 95% 置信区间：1.04–1.20），但不是雌激素（对照与 β-石竹烯；1.05 ± 0.03 与 1.07 ± 0.04，P= .69，对照的 95% 置信区间：0.96–1.12， β-石竹烯的 95% 置信区间： 0.98–1.15）。优点和局限性受试者的个人喜好和接触顺序可能会影响结果。结论对于性欲下降的女性来说，β-石竹烯可能是一种副作用较少的药物。我们相信β-石竹烯可能是治疗性欲减退女性的药物。然而，这一假设必须通过进一步的临床研究来检验。
IntroductionFrom previous studies, we hypothesized that olfactory exposure to β-caryophyllene stimulates women’s libido. However, Japan’s sex culture is so closed that it is difficult to test this possibility without accumulating scientific evidence. Therefore, it is necessary to measure the concentration of sex-related hormones in saliva, an experimental technique that is relatively easy to obtain research permission, and to obtain a scientific basis to convince ethics committee reviewers.AimThe aim of this study is to investigate whether β-caryophyllene increases salivary testosterone concentrations associated with libido and vaginal sensation during intercourse in women.Methods19 women in the follicular phase of the menstrual cycle participated in the study. The subjects then sat in front of the odor exposure device we had created. Each subject was exposed to dipropylene glycol for 20 minutes, followed by 3% β-caryophyllene for 20 minutes. Saliva was collected 4 times: before and after control exposure, and before and after β-caryophyllene exposure.Main Outcome MeasureSalivary testosterone and estrogen concentrations were measured with a competition ELISA.Resultsβ-caryophyllene significantly increased the salivary concentration of testosterone (control vs β-caryophyllene; 0.97 ± 0.05 vs 1.13 ± 0.03,P= .00, 95% confidence interval of control: 0.84–1.09, 95% confidence interval of β-caryophyllene: 1.04–1.20) but not estrogen (control vs β-caryophyllene; 1.05 ± 0.03 vs 1.07 ± 0.04,P= .69, 95% confidence interval of control: 0.96–1.12, 95% confidence interval of β-caryophyllene: 0.98–1.15).Strengths & LimitationsThe personal preferences of the subjects and the order of exposure may have affected the results.Conclusionβ-caryophyllene may be a remedy with fewer side effects for women with decreased libido. We believe that β-caryophyllene may be a remedy for women with decreased libido. However, this hypothesis must be tested by further clinical studies.
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DOI：
10.3390/molecules19078965
发表时间：
2014-06-27
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Qin XW;Hao CY;He SZ;Wu G;Tan LH;Xu F;Hu RS
通讯作者：
Hu RS
影响因子：
6.7
作者：
Dennerstein, L;Dudley, E;Burger, H
通讯作者：
Burger, H
自然受孕周期和非受孕周期中唾液类固醇分布的比较。
影响因子：
6.1
作者：
S. Lipson;P. T. Ellison
通讯作者：
P. T. Ellison
影响因子：
3.9
作者：
M.M Miller;K. Franklin
通讯作者：
K. Franklin
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
G. R. G. B. Webster-G.-R.-G.-B.-Webster-2298068370;E. C. Sharp;Am J Claas;Respir;D. E. Swayne;J. R. Beck;M. L. Perdue;C. W. Beard;C V Hunter;L. S. Tiley;H. M. Sang;J Chen;S. C. Chen;P. Stern;B. B. Scott-B.;C. Lois;S. Tiley;M. Hagen;J. T. Matthews;M. Krystal;J A Van Der Goot;G. Koch;M. C. De Jong;M. van Boven;J L Umbach;H. L. Yen;L. L. Poon-L.;B. R. Cullen;Mbio;F. Thomson;M. Hutchison;S. Gelstein;Y. Yeshurun;L. Rozenkrantz;S. Shushan;Idan Frumin;Y. Roth;N. Sobel
通讯作者：
G. R. G. B. Webster-G.-R.-G.-B.-Webster-2298068370;E. C. Sharp;Am J Claas;Respir;D. E. Swayne;J. R. Beck;M. L. Perdue;C. W. Beard;C V Hunter;L. S. Tiley;H. M. Sang;J Chen;S. C. Chen;P. Stern;B. B. Scott-B.;C. Lois;S. Tiley;M. Hagen;J. T. Matthews;M. Krystal;J A Van Der Goot;G. Koch;M. C. De Jong;M. van Boven;J L Umbach;H. L. Yen;L. L. Poon-L.;B. R. Cullen;Mbio;F. Thomson;M. Hutchison;S. Gelstein;Y. Yeshurun;L. Rozenkrantz;S. Shushan;Idan Frumin;Y. Roth;N. Sobel