Noninvasive OCT imaging of the retinal morphology and microvasculature based on the combination of the phase and amplitude method
Noninvasive OCT imaging of the retinal morphology and microvasculature based on the combination of the phase and amplitude method
复制标题
基于相位和幅度相结合的视网膜形态和微血管无创OCT成像
DOI：
10.1080/09500340.2016.1260779
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发表时间：
2017-04
影响因子：
1.3
通讯作者：
Chuanqing Zhou
中科院分区：
文献类型：
--
作者：
Lin Qin;Shanhui Fan;Chuanqing Zhou
摘要 为了在低扫描速度光学相干断层扫描（OCT）系统上实现光学相干断层扫描血管造影，我们开发了一种联合相位和幅度的方法，通过分析来自静止……的信号的频率分布来生成三维血管造影图像。
Abstract To implement the optical coherence tomography (OCT) angiography on the low scanning speed OCT system, we developed a joint phase and amplitude method to generate 3-D angiograms by analysing the frequency distribution of signals from non-moving and moving scatterers and separating the signals from the tissue and blood flow with high-pass filter dynamically. This approach firstly compensates the sample motion between adjacent A-lines. Then according to the corrected phase information, we used a histogram method to determine the bulk non-moving tissue phases dynamically, which is regarded as the cut-off frequency of a high-pass filter, and separated the moving and non-moving scatters using the mentioned high-pass filter. The reconstructed image can visualize the components of moving scatters flowing, and enables volumetric flow mapping combined with the corrected phase information. Furthermore, retinal and choroidal blood vessels can be simultaneously obtained by separating the B-scan into retinal part and choroidal parts using a simple segmentation algorithm along the RPE. After the compensation of axial displacements between neighbouring images, three-dimensional vasculature of ocular vessels has been visualized. Experiments were performed to demonstrate the effectiveness of the proposed method for 3-D vasculature imaging of human retina and choroid. The results revealed depth-resolved vasculatures in retina and choroid, suggesting that our approach can be used for noninvasive and three-dimensional angiography with a low-speed clinical OCT, and it has a great potential for clinic application.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
4.2
作者：
P. Henkind
通讯作者：
P. Henkind
影响因子：
4.4
作者：
Fingler, Jeff;Readhead, Carol;Fraser, Scott E.
通讯作者：
Fraser, Scott E.
影响因子：
13.7
作者：
Wojtkowski, M;Srinivasan, V;Duker, JS
通讯作者：
Duker, JS
影响因子：
3.8
作者：
White, BR;Pierce, MC;de Boer, JF
通讯作者：
de Boer, JF