Multivariate analysis of traumatic brain injury: development of an assessment score.
Multivariate analysis of traumatic brain injury: development of an assessment score.
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DOI：
10.3389/fneur.2015.00068
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发表时间：
2015
影响因子：
3.4
通讯作者：
Mueller GP
中科院分区：
文献类型：
--
作者：
Buonora JE;Yarnell AM;Lazarus RC;Mousseau M;Latour LL;Rizoli SB;Baker AJ;Rhind SG;Diaz-Arrastia R;Mueller GP
诊断和监测轻度创伤性脑损伤（mTBI）的重要挑战包括开发血浆生物标志物，用于评估神经损伤，监测发病机制，并预测发展不良神经结局的脆弱性。虽然几种生物标志物蛋白在这方面已经显示出前景，单独使用，但这些候选物缺乏足够的灵敏度和/或特异性来进行明确的诊断或鉴定处于后续病理学风险中的那些。本研究的目的是评估一组六个公认的和新的生物标志物候选人的TBI成人患者的评估。研究的生物标志物的选择是基于它们的相对脑特异性和反映TBI机制的独特特征的潜力，包括（1）通过神经元特异性烯醇化酶（NSE）和脑源性神经营养因子（BDNF）评估的神经元损伤，（2）通过过氧化物氧还蛋白6（PRDX 6）评估的氧化应激，（3）通过神经元特异性烯醇化酶（NSE）和脑源性神经营养因子（BDNF）评估的神经元损伤。（3）用胶质细胞酸性蛋白和S100钙结合蛋白β（S100 b）检测胶质细胞损伤和胶质细胞增生;（4）通过单核细胞趋化蛋白1/趋化因子评估的免疫活化（C-C基序）配体2（MCP 1/CCL 2）;和（5）通过细胞间粘附蛋白-5（ICAM-5）评估的细胞间粘附装置的破坏。PRDX 6、S100 b、MCP 1、NSE和BDNF的血浆水平的组合倍数变化导致TBI评估评分的形成，当与健康对照相比时，所述TBI评估评分鉴定具有0.97的受试者操作特征（ROC）曲线下面积的mTBI。这项研究表明，生物标志物反应的概况可用于制定对mTBI检测敏感的诊断评分。理想情况下，这种多变量评估策略将用额外的生物标志物进行改进，这些生物标志物可以有效地评估TBI的谱，并识别那些由于mTBI事件而具有发展神经病理学的特定风险的人。
Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include the development of plasma biomarkers for assessing neurologic injury, monitoring pathogenesis, and predicting vulnerability for the development of untoward neurologic outcomes. While several biomarker proteins have shown promise in this regard, used individually, these candidates lack adequate sensitivity and/or specificity for making a definitive diagnosis or identifying those at risk of subsequent pathology. The objective for this study was to evaluate a panel of six recognized and novel biomarker candidates for the assessment of TBI in adult patients. The biomarkers studied were selected on the basis of their relative brain-specificities and potentials to reflect distinct features of TBI mechanisms including (1) neuronal damage assessed by neuron-specific enolase (NSE) and brain derived neurotrophic factor (BDNF); (2) oxidative stress assessed by peroxiredoxin 6 (PRDX6); (3) glial damage and gliosis assessed by glial fibrillary acidic protein and S100 calcium binding protein beta (S100b); (4) immune activation assessed by monocyte chemoattractant protein 1/chemokine (C–C motif) ligand 2 (MCP1/CCL2); and (5) disruption of the intercellular adhesion apparatus assessed by intercellular adhesion protein-5 (ICAM-5). The combined fold-changes in plasma levels of PRDX6, S100b, MCP1, NSE, and BDNF resulted in the formulation of a TBI assessment score that identified mTBI with a receiver operating characteristic (ROC) area under the curve of 0.97, when compared to healthy controls. This research demonstrates that a profile of biomarker responses can be used to formulate a diagnostic score that is sensitive for the detection of mTBI. Ideally, this multivariate assessment strategy will be refined with additional biomarkers that can effectively assess the spectrum of TBI and identify those at particular risk for developing neuropathologies as consequence of a mTBI event.
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影响因子：
3.3
作者：
Fatma N;Kubo E;Toris CB;Stamer WD;Camras CB;Singh DP
通讯作者：
Singh DP
影响因子：
1.2
作者：
Carr, Marcus E., Jr.;Masullo, Lawrence N.;Lewis, Paul C.
通讯作者：
Lewis, Paul C.
影响因子：
3.9
作者：
Bruce, Jared;Echemendia, Ruben;Sisco, Amber
通讯作者：
Sisco, Amber
DOI：
10.1038/nrneurol.2014.65
发表时间：
2014-05-01
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Chase, Alex
通讯作者：
Chase, Alex
影响因子：
38.1
作者：
DeKosky, Steven T.;Blennow, Kaj;Ikonomovic, Milos D.;Gandy, Sam
通讯作者：
Gandy, Sam