Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016.
Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016.
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DOI：
10.1016/j.canep.2020.101667
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发表时间：
2020-04
影响因子：
2.6
通讯作者：
Hansen J
中科院分区：
文献类型：
--
作者：
Volk J;Heck JE;Schmiegelow K;Hansen J
父母的职业暴露被认为是儿童癌症的促成因素。使用丹麦登记系统确定年龄<=19岁、出生于丹麦并诊断为白血病、中枢神经系统（CNS）癌症和可能的产前启动癌症[肝母细胞瘤、髓母细胞瘤、肾母细胞瘤（肾母细胞瘤）、神经母细胞瘤、视网膜母细胞瘤和急性淋巴细胞白血病]的儿童。我们随机选择了25名年龄和性别相匹配的对照。父母和他们的就业历史是从全国登记处提取的。我们检查了父母双方围产期和产后的职业性粉尘暴露情况。采用条件Logistic回归估计比值比（OR）和95%置信区间（95%CI）。对于从出生到诊断都在工作的母亲，我们观察到木材暴露增加了白血病（OR 1.44，95%CI 1.08-1.94）和急性髓性白血病（OR 2.14，95%CI 1.13-4.03）的风险，纸尘暴露增加了CNS癌症的风险（OR 2.28，95%CI 1.22-4.26）。父亲接触木尘与两个时期的星形细胞瘤（OR 1.43，95%CI 1.05-1.96和1.42，1.09-1.86）和围产期的CNS癌（OR 1.24，95%CI 1.00-1.53）相关。木材工业中产前癌症风险增加是由神经母细胞瘤（OR 1.54，95% CI 1.03-2.29）和肝母细胞瘤（OR 2.41，95% CI 0.99-5.88）驱动的。出生后父母均在纺织厂工作的儿童患中枢神经系统癌症的OR为2.58（95%CI：1.10-6.05）。该研究表明，父母接触木尘可能会增加患特定儿童癌症的风险，这需要进一步关注。
Parental occupational exposures are suggested as contributing causes of childhood cancer. Children age<=19, born in Denmark and diagnosed with leukemia, central nervous system (CNS) cancers and likely prenatally initiated cancers [hepatoblastoma, medulloblastoma, Wilms tumor (nephroblastoma), neuroblastoma, retinoblastoma and acute lymphoid leukemia] were identified using Danish registries. We randomly selected twenty-five controls per case matched on age and sex. Parents and their employment histories were extracted from nationwide registries. We examined occupational dust exposures perinatally and postnatally in both parents. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression. For mothers working from birth to diagnosis, we observed increased risks of leukemia (OR 1.44, 95 % CI 1.08-1.94) and acute myeloid leukemia (OR 2.14, 95% CI 1.13-4.03) for wood exposures and increases (OR 2.28, 95% CI 1.22-4.26) in CNS cancers with paper dust exposure. Paternal exposure to wood dust was associated with astrocytoma in both periods (OR 1.43, 95% CI 1.05-1.96 and 1.42, 1.09-1.86, respectively) and CNS cancer (OR 1.24, 95% CI 1.00-1.53) in the perinatal period. An increased risk of prenatal cancers in the wood industries was driven by neuroblastoma (OR 1.54, 95% CI 1.03-2.29) and hepatoblastoma (OR 2.41, 95% CI 0.99-5.88). An OR 2.58 (95% CI: 1.10-6.05) for CNS cancer was found for both parents working in textile industries postnatally. The study suggests that parental exposure to wood dust may increase the risk of specific childhood cancers, which needs further attention.
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影响因子：
3.1
作者：
Kauppinen, Timo;Heikkila, Pirjo;Pukkala, Eero
通讯作者：
Pukkala, Eero
影响因子：
10.4
作者：
Colt, JS;Blair, A
通讯作者：
Blair, A
影响因子：
2.3
作者：
Cordier, S;Mandereau, L;Arslan, A
通讯作者：
Arslan, A
影响因子：
3.4
作者：
Gjerstorff, Marianne Lundkjaer
通讯作者：
Gjerstorff, Marianne Lundkjaer
影响因子：
6.4
作者：
BIRCH, JM;MARSDEN, HB
通讯作者：
MARSDEN, HB