Formulaic Language in Alzheimer's Disease.
Formulaic Language in Alzheimer's Disease.
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DOI：
10.1080/02687038.2012.757760
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发表时间：
2013-07-01
期刊：
影响因子：
2
通讯作者：
Van Lancker Sidtis D
中科院分区：
文献类型：
--
作者：
Bridges KA;Van Lancker Sidtis D
对阿尔茨海默病患者产出性语言的研究主要集中在句法和语义的形式测试上，而对自然主义语篇和公式化语言的研究较少。临床观察表明，AD患者在其他认知能力恶化后很长时间内仍能保持产生公式化语言的能力。本研究量化了AD患者自发言语中公式化表达的产生。比较了早发和晚发性疾病的患者。对早发性AD患者（n = 5）和晚发性AD患者（n = 6）以及健康对照组（n = 5）的对话语言样本进行分析，以确定公式化语言（以公式化表达中的单词数量为衡量标准）是否在组间存在差异。结果表明，AD患者，无论发病年龄，使用显着更多的公式化表达比健康对照组。早发和晚发AD组在公式化语言测量方面没有差异。这些发现有助于大脑功能的双重过程模型，提出了不同的公式化和新颖的表达的处理原则。在这个模型中，皮层下区域在阿尔茨海默病的晚期仍然保持完整，在公式化语言的产生中发挥着重要作用。临床实践中的应用包括识别保存公式化语言和提供知情的咨询，病人和家人。
Studies of productive language in Alzheimer’s disease (AD) have focused on formal testing of syntax and semantics but have directed less attention to naturalistic discourse and formulaic language. Clinical observations suggest that individuals with AD retain the ability to produce formulaic language long after other cognitive abilities have deteriorated. This study quantifies production of formulaic expressions in the spontaneous speech of individuals with AD. Persons with early- and late-onset forms of the disease were compared. Conversational language samples of individuals with early- (n = 5) and late-onset (n = 6) AD and healthy controls (n = 5) were analyzed to determine whether formulaic language, as measured by the number of words in formulaic expressions, differs between groups. Results indicate that individuals with AD, regardless of age of onset, used significantly more formulaic expressions than healthy controls. The early- and late-onset AD groups did not differ on formulaic language measures. These findings contribute to a dual process model of cerebral function, which proposes differing processing principles for formulaic and novel expressions. In this model, subcortical areas, which remain intact into late in the progression of Alzheimer’s disease, play an important role in the production of formulaic language. Applications to clinical practice include identifying preserved formulaic language and providing informed counseling to patient and family.
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影响因子：
1.2
作者：
Conner PS;Hyun J;O'Connor Wells B;Anema I;Goral M;Monéreau-Merry MM;Rubino D;Kuckuk R;Obler LK
通讯作者：
Obler LK
影响因子：
2.5
作者：
GLOSSER, G;KAPLAN, E
通讯作者：
KAPLAN, E
影响因子：
3.7
作者：
GLOSSER, G;FRIEDMAN, RB
通讯作者：
FRIEDMAN, RB
影响因子：
3.7
作者：
Kemper, S;Greiner, LH;Mitzner, TL
通讯作者：
Mitzner, TL
影响因子：
2.7
作者：
Graybiel, AM
通讯作者：
Graybiel, AM