Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.
Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.
复制标题
了解宇航员微生物组的复杂性和变化，以成功执行长期太空任务。
DOI：
10.3390/life12040495
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发表时间：
2022-03-28
期刊：
影响因子：
3.2
通讯作者：
Urbaniak, Camilla
中科院分区：
文献类型：
--
作者：
Tesei, Donatella;Jewczynko, Anna;Lynch, Anne;Urbaniak, Camilla
在太空任务中，宇航员面临着各种太空飞行所特有的挑战，这些挑战在一段时间内会引起人类的生理变化。其中一些变化发生在微生物组水平，这是一个复杂的微生物群落集合，存在于人体的各个解剖部位，在调节宿主的健康和行为方面发挥着关键作用。微生物组对日常生理活动至关重要，微生物组组成和功能的改变与各种人类疾病有关。由于这些原因，了解航天飞行和空间条件对宇航员微生物组的影响对于评估长期任务期间可能出现的重大健康风险和制定对策至关重要。在这里，我们回顾了长期太空探索引起的各种疾病，并讨论了微生物组在促进或改善这些疾病中的作用，以及影响微生物组组成的空间相关因素。探讨的主题涉及微重力、辐射、免疫、骨骼健康、认知功能、性别差异和药物微生物学。在太空飞行、宿主和微生物组的三重作用之间建立了联系，以及这些相互作用对成功的长期太空任务的重要性。
During space missions, astronauts are faced with a variety of challenges that are unique to spaceflight and that have been known to cause physiological changes in humans over a period of time. Several of these changes occur at the microbiome level, a complex ensemble of microbial communities residing in various anatomic sites of the human body, with a pivotal role in regulating the health and behavior of the host. The microbiome is essential for day-to-day physiological activities, and alterations in microbiome composition and function have been linked to various human diseases. For these reasons, understanding the impact of spaceflight and space conditions on the microbiome of astronauts is important to assess significant health risks that can emerge during long-term missions and to develop countermeasures. Here, we review various conditions that are caused by long-term space exploration and discuss the role of the microbiome in promoting or ameliorating these conditions, as well as space-related factors that impact microbiome composition. The topics explored pertain to microgravity, radiation, immunity, bone health, cognitive function, gender differences and pharmacomicrobiomics. Connections are made between the trifecta of spaceflight, the host and the microbiome, and the significance of these interactions for successful long-term space missions.
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影响因子：
5.2
作者：
Amabebe E;Anumba DOC
通讯作者：
Anumba DOC
影响因子：
5.1
作者：
Allen, Christopher A.;Niesel, David W.;Torres, Alfredo G.
通讯作者：
Torres, Alfredo G.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
5.6
作者：
Alauzet C;Cunat L;Wack M;Lanfumey L;Legrand-Frossi C;Lozniewski A;Agrinier N;Cailliez-Grimal C;Frippiat JP
通讯作者：
Frippiat JP
影响因子：
5.2
作者：
Aunins TR;Erickson KE;Prasad N;Levy SE;Jones A;Shrestha S;Mastracchio R;Stodieck L;Klaus D;Zea L;Chatterjee A
通讯作者：
Chatterjee A