Separating function from structure in perfusion imaging of the aging brain.
Separating function from structure in perfusion imaging of the aging brain.
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DOI：
10.1002/hbm.20719
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发表时间：
2009-09
影响因子：
4.8
通讯作者：
Stern, Yaakov
中科院分区：
文献类型：
--
作者：
Asllani, Iris;Habeck, Christian;Borogovac, Ajna;Brown, Truman R.;Brickman, Adam M.;Stern, Yaakov
关键词：
人类脑血流成像方法的准确性一直受到部分体积效应（PVE）的阻碍，这是空间分辨率有限的结果。由于脑萎缩，PVE在老年人成像中可能特别成问题，并且可能大大高估与年轻人的CBF差异。本研究的主要目的是将老年人的结构性下降与真正的CBF减少区分开来。为此，对自旋回声EPI连续动脉自旋标记MRI获得的CBF图像（体素大小= 3.4 × 3.4 × 8 mm3）应用pve校正算法。在老年人（N = 30）和年轻人（N = 26）中获得了独立于体素组织分数体积的组织特异性CBF图像；平均年龄差为43岁。在全球范围内，pve校正的灰质CBF在老年人和年轻人中分别为88.2±16.1和107.3±17.5 mL/100g min。在额叶中发现了最大的PVE贡献，在男性和女性之间与年龄相关的CBF差异中分别增加了10%和12%。研究发现，老年人的gm - wm脑容量比平均为3.5，年轻人为3.9。全脑体向比较显示，男性的前扣带（双侧）、尾状核（双侧）、扣带回（双侧）、楔叶（左）、额下回（左）、脑岛（左）、额中回（左）、楔前叶（双侧）、前额叶皮质（双侧）、额上回（双侧）和女性的杏仁核（双侧）、下丘脑（左）、海马（双侧）和额中回（右）的CBF明显减少。
The accuracy of the cerebral blood flow (CBF) imaging methods in humans has been impeded by the partial volume effects (PVE), which are a consequence of the limited spatial resolution. Because of brain atrophy, PVE can be particularly problematic in imaging the elderly and can considerably overestimate the CBF difference with the young. The primary goal of this study was to separate the structural decline from the true CBF reduction in elderly. To this end, a PVE-correction algorithm was applied on the CBF images acquired with spin-echo EPI continuous arterial spin labeling MRI (voxel size = 3.4 × 3.4 × 8 mm3). Tissue-specific CBF images that were independent of voxels’ tissue fractional volume were obtained in elderly (N = 30) and young (N = 26); mean age difference was 43 years. Globally, PVE-corrected gray matter CBF was 88.2 ± 16.1 and 107.3±17.5 mL/100g min in elderly and young, respectively. The largest PVE contribution was found in the frontal lobe and accounted for an additional 10% and 12% increase in the age-related CBF difference between men and women, respectively. The GM-to-WM CBF ratios were found to be on average 3.5 in elderly and 3.9 in young. Whole brain voxelwise comparisons showed marked CBF decrease in anterior cingulate (bilateral), caudate (bilateral), cingulate gyrus (bilateral), cuneus (left), inferior frontal gyrus (left), insula (left), middle frontal gyrus (left), precuneus (bilateral), prefrontal cortex (bilateral), superior frontal gyrus (bilateral) in men and amygdala (bilateral), hypothalamus (left), hippocampus (bilateral), and middle frontal gyrus (right) in women.
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影响因子：
10.6
作者：
Schmidt, K;Sokoloff, L
通讯作者：
Sokoloff, L
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
3.3
作者：
Parkes, LM;Rashid, W;Tofts, PS
通讯作者：
Tofts, PS
DOI：
10.1097/00004647-199611000-00019
发表时间：
1996-11-01
影响因子：
6.3
作者：
Alsop, DC;Detre, JA
通讯作者：
Detre, JA
DOI：
10.1097/01.wcb.0000071887.63724.b2
发表时间：
2003-07-01
影响因子：
6.3
作者：
Brown, GG;Zorrilla, LTE;Buxton, RB
通讯作者：
Buxton, RB