Antimicrobial resistance mechanisms among Campylobacter.
Antimicrobial resistance mechanisms among Campylobacter.
复制标题
DOI：
10.1155/2013/340605
复制
发表时间：
2013
影响因子：
--
通讯作者：
Osek J
中科院分区：
文献类型：
--
作者：
Wieczorek K;Osek J
空肠弯曲菌和结肠弯曲菌是世界上最常见的细菌性胃肠炎的病原体。人类最常被受污染的食物感染，特别是未煮熟的鸡肉，但也有其他细菌来源的描述。弯曲杆菌病通常是一种自限性疾病。只有那些病情更严重和免疫功能低下的患者才需要抗菌治疗。用于治疗弯曲杆菌感染的最常见的抗微生物剂是大环内酯类，如红霉素，和氟喹诺酮类，如环丙沙星。四环素类已被建议作为临床弯曲菌病治疗的替代选择，但在实践中并不经常使用。然而，在过去的几十年中，越来越多的耐药弯曲杆菌分离株已对氟喹诺酮类和其他抗菌剂如大环内酯类、氨基糖苷类和β-内酰胺类产生耐药性。抗生素耐药性的趋势表明，兽医和动物生产中抗生素的使用与人类中弯曲杆菌的耐药性分离株之间存在明显的相关性。在这篇综述中，新出现的耐药模式的抗菌药物用于治疗疾病的介绍和这些药物的耐药机制进行了讨论。
Campylobacter jejuni and Campylobacter coli are recognized as the most common causative agents of bacterial gastroenteritis in the world. Humans most often become infected by ingesting contaminated food, especially undercooked chicken, but also other sources of bacteria have been described. Campylobacteriosis is normally a self-limiting disease. Antimicrobial treatment is needed only in patients with more severe disease and in those who are immunologically compromised. The most common antimicrobial agents used in the treatment of Campylobacter infections are macrolides, such as erythromycin, and fluoroquinolones, such as ciprofloxacin. Tetracyclines have been suggested as an alternative choice in the treatment of clinical campylobacteriosis but in practice are not often used. However, during the past few decades an increasing number of resistant Campylobacter isolates have developed resistance to fluoroquinolones and other antimicrobials such as macrolides, aminoglycosides, and beta-lactams. Trends in antimicrobial resistance have shown a clear correlation between use of antibiotics in the veterinary medicine and animal production and resistant isolates of Campylobacter in humans. In this review, the patterns of emerging resistance to the antimicrobial agents useful in treatment of the disease are presented and the mechanisms of resistance to these drugs in Campylobacter are discussed.
登录
查看更多内容
影响因子：
5.2
作者：
ENDTZ, HP;RUIJS, GJ;MOUTON, RP
通讯作者：
MOUTON, RP
影响因子：
4.9
作者：
Cagliero, Cedric;Mouline, Christian;Payot, Sophie
通讯作者：
Payot, Sophie
影响因子：
3.6
作者：
de Boer, P;Wagenaar, JA;Duim, B
通讯作者：
Duim, B
影响因子：
5.2
作者：
Bester, L. A.;Essack, S. Y.
通讯作者：
Essack, S. Y.
影响因子：
5.2
作者：
Delsol, AA;Sunderland, J;Roe, JM
通讯作者：
Roe, JM