Cell Fusion: Merging Membranes and Making Muscle.
Cell Fusion: Merging Membranes and Making Muscle.
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DOI:
10.1016/j.tcb.2019.09.002
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发表时间:
2019-12
影响因子:
19
通讯作者:
Millay DP
中科院分区:
文献类型:
--
作者:
Petrany MJ;Millay DP
Cell fusion is essential for the development of multicellular organisms, and plays a key role in the formation of various cell types and tissues. Recent findings have highlighted the varied protein machinery that drives plasma-membrane merger in different systems, which is characterized by diverse structural and functional elements. We highlight the discovery and activities of several key sets of fusion proteins that together offer an evolving perspective on cell membrane fusion. We also emphasize recent discoveries in vertebrate myoblast fusion in skeletal muscle, which is composed of numerous multinucleated myofibers formed by the fusion of progenitor cells during development.
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