Cell Fusion: Merging Membranes and Making Muscle.

Cell Fusion: Merging Membranes and Making Muscle.
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DOI:
10.1016/j.tcb.2019.09.002
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发表时间:
2019-12
影响因子:
19
通讯作者:
Millay DP
Millay DP
中科院分区:
生物学1区
文献类型:
--
作者:
Petrany MJ;Millay DP

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细胞融合对于多细胞生物的发育是必不可少的,并且在各种细胞类型和组织的形成中起着关键作用。最近的研究结果强调了在不同系统中驱动质膜合并的不同蛋白质机制,其特征在于具有不同的结构和功能元件。我们强调了几组关键融合蛋白的发现和活动,它们共同提供了一个不断发展的细胞膜融合的视角。我们还强调了最近发现的脊椎动物骨骼肌成肌细胞融合,这是由许多多核肌纤维形成的祖细胞在发育过程中融合。
Cell fusion is essential for the development of multicellular organisms, and plays a key role in the formation of various cell types and tissues. Recent findings have highlighted the varied protein machinery that drives plasma-membrane merger in different systems, which is characterized by diverse structural and functional elements. We highlight the discovery and activities of several key sets of fusion proteins that together offer an evolving perspective on cell membrane fusion. We also emphasize recent discoveries in vertebrate myoblast fusion in skeletal muscle, which is composed of numerous multinucleated myofibers formed by the fusion of progenitor cells during development.
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