Innate immune biology in age-related macular degeneration.
Innate immune biology in age-related macular degeneration.
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年龄相关性黄斑变性中的固有免疫生物学。
DOI：
10.3389/fcell.2023.1118524
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
视网膜相关性黄斑变性（AMD）是一种神经退行性疾病，是发达国家不可逆视力丧失的主要原因。虽然没有被经典地描述为炎性疾病，但越来越多的证据表明先天免疫系统的几种成分参与了年龄相关性黄斑变性的病理生理学。特别是，补体激活、小胶质细胞参与和血视网膜屏障破坏已被证明在疾病进展和随后的视力丧失中起关键作用。这篇综述讨论了先天免疫系统在年龄相关性黄斑变性中的作用，以及单细胞转录组学的最新进展，有助于促进对年龄相关性黄斑变性的理解和治疗。我们还探讨了先天免疫激活背景下年龄相关性黄斑变性的几个潜在治疗靶点。
Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.
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新生血管相关的黄斑变性中的循环单核细胞和B淋巴细胞。
DOI：
10.2147/opth.s121332
发表时间：
2017
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Hector SM;Sørensen TL
通讯作者：
Sørensen TL
影响因子：
--
作者：
Chen, Jinquan;Zhao, Long;Ding, Xuanheng;Wen, Yan;Wang, Lingda;Shu, Qinxin;Xie, Wenxi;Liu, Yanyao;Peng, H.
通讯作者：
Peng, H.
影响因子：
4.4
作者：
Kataoka, Keiko;Nishiguchi, Koji M.;Terasaki, Hiroko
通讯作者：
Terasaki, Hiroko
影响因子：
13.7
作者：
Faber, Carsten;Singh, Amardeep;Nissen, Mogens Holst
通讯作者：
Nissen, Mogens Holst
影响因子：
4.4
作者：
Goverdhan, Srinivas V.;Khakoo, Salim I.;Lotery, Andrew J.
通讯作者：
Lotery, Andrew J.