Aβ1-40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration.
Aβ1-40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration.
复制标题
DOI：
10.1155/2022/6489923
复制
发表时间：
2022
影响因子：
--
通讯作者：
Peng, H.
中科院分区：
文献类型：
--
作者：
Chen, Jinquan;Zhao, Long;Ding, Xuanheng;Wen, Yan;Wang, Lingda;Shu, Qinxin;Xie, Wenxi;Liu, Yanyao;Peng, H.
中性粒细胞参与人类先天免疫系统的进步，并对感知到的内源性和外源性威胁作出反应。作为一种应答机制，中性粒细胞胞外陷阱（NETs）在免疫应答过程中在病原体和周围组织附近形成。Drusen是老年性黄斑变性（Age-Related Macular Degeneration， AMD）的重要标志物，在AMD的病程中起着重要作用。Aβ1-40是木参的主要成分。然而，NETs与AMD或a - β1-40之间的关系尚不清楚。在这里，我们发现AMD患者血清中NETs水平升高，小鼠模型血清中NETs水平升高。我们还观察到小鼠视网膜中中性粒细胞的积累。此外，PAD4抑制剂可抑制NETs的产生，从而减轻慢性炎症。此外，我们证实了a - β1-40可以通过toll样受体4 （TLR4）和中性粒细胞NADPH氧化酶（NOX）途径诱导NETs的形成。我们的研究证实了NETs的形成是由a - β1 - 40诱导的，结果表明NETs可能在AMD的发病过程中起重要作用。
Neutrophils participate in the advancement of the human innate immune system and respond to perceived endogenous and exogenous threats. As a response mechanism, neutrophil extracellular traps (NETs) form near pathogens and surrounding tissues during an immune response. Drusen is an important marker of Age-Related Macular Degeneration (AMD) and plays an important role in the course of AMD. Aβ1-40 is the main component of drusen. However, the relationship between NETs and AMD or Aβ1-40 is unclear. Here, we found elevated levels of NETs in the serum of AMD patients and elevated levels in the serum of mouse models. We also observed the accumulation of neutrophils in the mouse retina. In addition, the production of NETs was inhibited by PAD4 inhibitors, which can alleviate chronic inflammation. Moreover, we confirmed that Aβ1-40 can induce NETs formation via the Toll-like receptor 4 (TLR4) and neutrophil NADPH oxidase (NOX) pathways. Our study confirmed that the formation of NETs is induced by Aβ1–40, and the results suggest that NETs may play a vital role in AMD pathogenesis.
登录
查看更多内容
AMD中的补体因子H：桥接遗传关联和病理生物学。
影响因子：
17.8
作者：
Toomey CB;Johnson LV;Bowes Rickman C
通讯作者：
Bowes Rickman C
影响因子：
12.7
作者：
Roos TT;Garcia MG;Martinsson I;Mabrouk R;Israelsson B;Deierborg T;Kobro-Flatmoen A;Tanila H;Gouras GK
通讯作者：
Gouras GK
影响因子：
7.3
作者：
Fine N;Tasevski N;McCulloch CA;Tenenbaum HC;Glogauer M
通讯作者：
Glogauer M
影响因子：
5.4
作者：
Liu, Chaoqi;Cao, Lining;Xu, Ding
通讯作者：
Xu, Ding
DOI：
10.1146/annurev-genom-090413-025610
发表时间：
2014
影响因子：
8.7
作者：
Fritsche LG;Fariss RN;Stambolian D;Abecasis GR;Curcio CA;Swaroop A
通讯作者：
Swaroop A