Tissue engineered constructs for peripheral nerve surgery.
Tissue engineered constructs for peripheral nerve surgery.
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DOI：
10.1007/s10353-013-0205-0
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发表时间：
2013-06
影响因子：
0.6
通讯作者：
Mackinnon, S. E.
中科院分区：
文献类型：
--
作者：
Johnson, P. J.;Wood, M. D.;Moore, A. M.;Mackinnon, S. E.
关键词：
组织工程被定义为“一个跨学科领域，应用工程学和生命科学的原理来开发恢复、维持或改善组织功能或整个器官的生物替代品”。外伤性周围神经损伤导致损伤区域显着的组织损失，因此需要桥或支架来使轴突从近端残端再生到远端残端。通过文献综述来提供有关开发组织工程周围神经替代品所需成分的信息。然后，对致力于这一目标的研究组成的文献进行了全面的回顾。广泛的研究致力于开发组织工程周围神经替代品，作为从近端神经残端再生轴突寻找远端神经的桥梁。理想情况下，这种神经替代物将由模仿周围神经细胞外基质的支架组件和用于刺激和支持周围神经轴突再生的细胞组件组成。组织工程领域应该考虑其挑战，不仅要满足自体移植的“黄金标准”，还要了解驱动和抑制神经再生的因素，以便超越自体移植的结果。
Tissue engineering has been defined as “an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ”. Traumatic peripheral nerve injury resulting in significant tissue loss at the zone of injury necessitates the need for a bridge or scaffold for regenerating axons from the proximal stump to reach the distal stump. A review of the literature was used to provide information on the components necessary for the development of a tissue engineered peripheral nerve substitute. Then, a comprehensive review of the literature is presented composed of the studies devoted to this goal. Extensive research has been directed toward the development of a tissue engineered peripheral nerve substitute to act as a bridge for regenerating axons from the proximal nerve stump seeking the distal nerve. Ideally this nerve substitute would consist of a scaffold component that mimics the extracellular matrix of the peripheral nerve and a cellular component that serves to stimulate and support regenerating peripheral nerve axons. The field of tissue engineering should consider its challenge to not only meet the autograft “gold standard” but also to understand what drives and inhibits nerve regeneration in order to surpass the results of an autograft.
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DOI：
10.1073/pnas.0501263102
发表时间：
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影响因子：
11.1
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