Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.
Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.
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DOI：
10.1155/2015/563425
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发表时间：
2015
影响因子：
--
通讯作者：
Terrazas LI
中科院分区：
文献类型：
--
作者：
Ledesma-Soto Y;Callejas BE;Terrazas CA;Reyes JL;Espinoza-Jiménez A;González MI;León-Cabrera S;Morales R;Olguín JE;Saavedra R;Oghumu S;Satoskar AR;Terrazas LI
肠黏膜的慢性炎症是炎症性肠道疾病的特征，如溃疡性结肠炎和克罗恩病。寄生虫已经发展出免疫调节策略，可能会影响几种炎症性疾病的结局。因此，我们研究了粗带绦虫感染能否减轻葡聚糖硫酸钠(DSS-)诱导的BALB/c和C57BL/6小鼠溃疡性结肠炎的炎症反应。预感染显著减少了DSS诱导的结肠炎的表现，如体重减轻和结肠长度缩短，并降低了疾病活动指数，与小鼠的遗传背景无关。带绦虫感染后全身促炎细胞因子水平降低，IL-4和IL-10水平升高，结肠炎性渗出也明显减少。来自结肠的RT-PCR分析显示，与未感染DSS的小鼠相比，感染粗圆线虫的小鼠显示出精氨酸酶-1的表达增加，但iNOS的表达减少。T调节细胞百分率未见增加。将交替激活的巨噬细胞(Ф，S)从感染的小鼠体内过继转移到DSS诱导的结肠炎小鼠体内，降低了结肠炎的严重程度。给予吲哚美辛可阻断带绦虫的抗政治作用。因此，粗糙毛滴虫感染通过抑制与aAM、Ф、S和前列腺素有关的炎症反应来限制溃疡性结肠炎的病理。
Chronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB/c and C57BL/6 mice. Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice. Taenia infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced. RT-PCR assays from colon showed that T. crassiceps-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice. The percentages of T regulatory cells were not increased. The adoptive transfer of alternatively activated macrophages (AAMФs) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation. Administration of indomethacin abrogated the anticolitic effect of Taenia. Thus, T. crassiceps infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAMФs and prostaglandins.
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影响因子：
5.4
作者：
Elliott, DE;Setiawan, T;Weinstock, JV
通讯作者：
Weinstock, JV
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM
影响因子：
4.9
作者：
Leung, John;Hang, Long;Blum, Arthur;Setiawan, Tommy;Stoyanoff, Korynn;Weinstock, Joel
通讯作者：
Weinstock, Joel
影响因子：
--
作者：
Melon A;Wang A;Phan V;McKay DM
通讯作者：
McKay DM
影响因子：
2.1
作者：
Mo, Hong-mei;Liu, Wen-qi;Li, Yong-long
通讯作者：
Li, Yong-long