Unexpected guests in the tumor microenvironment: microbiome in cancer.
Unexpected guests in the tumor microenvironment: microbiome in cancer.
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DOI：
10.1007/s13238-020-00813-8
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发表时间：
2021-05
期刊：
影响因子：
21.1
通讯作者：
Jin C
中科院分区：
文献类型：
--
作者：
Wong-Rolle A;Wei HK;Zhao C;Jin C
虽然肠道微生物组已被确定为癌症发生和治疗反应的重要生物标志物和调节因子，但对微生物组在癌症其他部位的作用知之甚少。新出现的证据表明，在许多类型的癌症中，局部微生物区系构成了肿瘤微环境的重要组成部分，特别是在发生在包括肺、皮肤和胃肠道在内的粘膜部位的癌症中。肿瘤内的细菌种群被发现是肿瘤类型特有的，机制研究表明，肿瘤相关微生物区系可能直接调节癌症的发生、发展和对化疗或免疫治疗的反应。本文就癌组织中的微生物区系及其在肿瘤发生和治疗中的作用和作用机制等方面的重要文献作一综述。
Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
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影响因子：
8.3
作者：
Dickson, Robert P.;Erb-Downward, John R.;Curtis, Jeffrey L.
通讯作者：
Curtis, Jeffrey L.
影响因子：
3.7
作者：
Cameron SJS;Lewis KE;Huws SA;Hegarty MJ;Lewis PD;Pachebat JA;Mur LAJ
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Mur LAJ
影响因子：
168.9
作者：
Dickson, Robert P.;Martinez, Fernando J.;Huffnagle, Gary B.
通讯作者：
Huffnagle, Gary B.
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3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
影响因子：
4.6
作者：
Gomes, Silvia;Cavadas, Bruno;Seixas, Susana
通讯作者：
Seixas, Susana