Role of 5-HT1A in the nucleus of the solitary tract in the regulation of swallowing activities evoked by electroacupuncture in anesthetized rats
Role of 5-HT1A in the nucleus of the solitary tract in the regulation of swallowing activities evoked by electroacupuncture in anesthetized rats
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孤束核5-HT1A在电针诱发麻醉大鼠吞咽活动调节中的作用
DOI：
10.1016/j.neulet.2018.06.018
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发表时间：
2018-11
影响因子：
2.5
通讯作者：
Jian-hua Liu
中科院分区：
文献类型：
--
作者：
Hui You;Shaowen Hu;Qiu-ping Ye;Feng Wang;Jian-peng Huang;Yi-ling Yang;Wen-bin Fu;Neng-gui Xu;Jian-hua Liu
躯体刺激疗法，如电针，已广泛应用于临床治疗吞咽障碍。然而，其潜在的机制仍然未知。本实验观察了电针风府、莲泉穴对麻醉大鼠吞咽活动的影响及孤束核内5-HT_（1A）的参与。电针DU_（16）和RN_（23）可引起下颌舌骨肌肌电活动，NTS内注射10 nmol 5-HT_（1A）拮抗剂（WAY-100635）可使其减弱。电针后孤束核5-HT 1A表达增加。结果提示：电针DU_（16）和RN_（23）促进吞咽活动，孤束核内5-HT_（1A）可能在这种兴奋效应中起重要作用。
Somatic stimulation therapy, such as electroacupuncture (EA), has been widely applied in the clinic to treat dysphagia. However, its underlying mechanism has remained unknown. In the present study, the effect of EA at acupoints Fengfu (DU16) and Lianquan (RN23) on swallowing activities and the involvement of 5-HT1Ain the nucleus of the solitary tract (NTS) were examined in anesthetized rats. EA at DU16 and RN23 significantly evoked myoelectric activity of the mylohyoid muscle, which was attenuated by injection of 10 nmol 5-HT1Aantagonist (WAY-100635) into the NTS. Meanwhile, 5-HT1Aexpression in the NTS increased following EA. The results suggested that EA at DU16 and RN23 promotes swallowing activity, and 5-HT1Ain the NTS may play an important role in the excitatory effects.
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影响因子：
1.7
作者：
JEAN, A
通讯作者：
JEAN, A
DOI：
10.1254/jjp.88.459
发表时间：
2002-04
期刊：
Japanese journal of pharmacology
影响因子：
--
作者：
Yuki Iwahori;Y. Ikegaya;N. Matsuki
通讯作者：
Yuki Iwahori;Y. Ikegaya;N. Matsuki
影响因子：
2.6
作者：
Nam, Hyung Seok;Beom, Jaewon;Han, Tai Ryoon
通讯作者：
Han, Tai Ryoon
影响因子：
2
作者：
J. Kessler;A. Jean
通讯作者：
J. Kessler;A. Jean
影响因子：
2.5
作者：
MANAKER, S;VERDERAME, HM
通讯作者：
VERDERAME, HM